Previous studies in mainly European populations have reported that the gut microbiome
composition is associated with the human genome. However, the genotype-microbiome …

Previous genetic studies of venous thromboembolism (VTE) have been largely limited to
common variants, leaving the genetic determinants relatively incomplete. We performed an …

Quantitative genetics in Caenorhabditis elegans seeks to identify naturally segregating
genetic variants that underlie complex traits. Genome-wide association studies scan the …

Fatty acid metabolism, including β-oxidation (βOX), plays an important role in human
physiology and pathology. βOX is an essential process in the energy metabolism of most …

Background'Benign ethnic neutropenia'(BEN) is a heritable condition characterized by lower
neutrophil counts, predominantly observed in individuals of African ancestry, and the genetic …

Asthma is a complex heterogeneous disease caused by gene–environment interactions.
Although numerous genome-wide association studies have been conducted, these …

Background Concurrent variation in adiposity and inflammation suggests potential shared
functional pathways and pleiotropic disease underpinning. Yet, exploration of pleiotropy in …

The phenotypic impact of genetic variation of repetitive features in the human genome is
currently understudied. One such feature is the multi-copy 47S ribosomal DNA (rDNA) that …

Inadequate representation of non-European ancestry populations in genome-wide
association studies (GWAS) has limited opportunities to isolate functional variants. Fine …

ABSTRACT A central goal of evolutionary genetics in Caenorhabditis elegans is to
understand the genetic basis of traits that contribute to adaptation and fitness. Genome-wide …