Bone is a dynamic tissue constantly responding to environmental changes such as
nutritional and mechanical stress. Bone homeostasis in adult life is maintained through bone …

Highlights•Parathyroid hormone has dual anabolic and catabolic actions on the
skeleton.•The OPG–RANKL–RANK pathway is the main mediator of the catabolic actions of …

Bone remodeling is a tightly controlled mechanism in which osteoblasts (OB), the cells
responsible for bone formation, osteoclasts (OC), the cells specialized for bone resorption …

Runx2 is a master transcription factor for osteogenesis. The most important phenomenon
that makes this protein a master regulator for osteogenesis is its structural integrity. In …

Parathyroid hormone (PTH) exerts profound effects on skeletal homeostasis through
multiple cellular and molecular mechanisms. Continuous hyperparathyroidism causes net …

Intermittent administration of parathyroid hormone (PTH) stimulates bone formation by
increasing osteoblast number, but the molecular and cellular mechanisms underlying this …

Both chronic excess of PTH, as in hyperparathyroidism, and intermittent elevation of PTH (by
daily injections) increase the number of osteoblasts; albeit, the former is associated with …

Osteogenesis is the process of new bone formation where transcription factors play an
important role in controlling cell proliferation and differentiation. Runt-related transcription …

Osteoporosis is a serious health problem that diminishes quality of life and levies a financial
burden on those who fear and experience bone fractures. Physical activity as a way to …

A Review of Osteocyte Function and the Emerging Importance o... : JBJS A Review of Osteocyte
Function and the Emerging Importance of Sclerostin : JBJS JBJS Journal Case Connector …