Recent advances in gadolinium based contrast agents for bioimaging applications

A Fatima, MW Ahmad, AKA Al Saidi, A Choudhury… - Nanomaterials, 2021 - mdpi.com
Gadolinium (Gd) based contrast agents (CAs)(Gd-CAs) represent one of the most advanced
developments in the application of Gd for magnetic resonance imaging (MRI). Current …

Molecular Design of Magnetic Resonance Imaging Agents Binding to Amyloid Deposits

A Nikiforova, I Sedov - International Journal of Molecular Sciences, 2023 - mdpi.com
The ability to detect and monitor amyloid deposition in the brain using non-invasive imaging
techniques provides valuable insights into the early diagnosis and progression of …

Multimodal Theranostic Cyanine-Conjugated Gadolinium(III) Complex for In Vivo Imaging of Amyloid-β in an Alzheimer's Disease Mouse Model

X Wang, HN Chan, N Desbois, CP Gros… - … Applied Materials & …, 2021 - ACS Publications
Despite the wide use of magnetic resonance imaging (MRI) as a clinical diagnostic tool,
there are still no clinically approved MRI contrast agents that can be applied for cerebral …

A Near-infrared Fluorescence and Positron Emission Tomography Bimodal Probe for In Vivo Imaging of Amyloid-β Species

D Fang, D Pan, X Wen, J Zhang, M Yang… - ACS Chemical …, 2024 - ACS Publications
Noninvasive imaging of amyloid-β (Aβ) species in vivo is important for the early diagnosis of
Alzheimer's disease (AD). In this paper, we report a near-infrared (NIR) fluorescence (FL) …

An AIE-Active NIR Fluorescent Probe with Good Water Solubility for the Detection of Aβ1–42 Aggregates in Alzheimer's Disease

YM Ji, M Hou, W Zhou, ZW Ning, Y Zhang, GW Xing - Molecules, 2023 - mdpi.com
Alzheimer's disease (AD), an amyloid-related disease, seriously endangers the health of
elderly individuals. According to current research, its main pathogenic factor is the amyloid …

[HTML][HTML] Advances in multi-target fluorescent probes for imaging and analyzing biomarkers in Alzheimer's disease

C Zhu, J Han, F Liang, M Zhu, G Zhang… - Coordination Chemistry …, 2024 - Elsevier
Alzheimer's disease (AD) is a neurodegenerative condition that poses multiple challenges
for disease diagnosis and treatment. Biomarker-based assays are one of the important tools …

Functionalized graphene-based electrochemical array sensors for the identification of distinct conformational states of Amyloid Beta in Alzheimer's disease

H Ji, X Kang, X Yang, H Chen, T Mao, Y He… - Biosensors and …, 2023 - Elsevier
Aβ oligomers have been widely accepted as significant biomarkers for Alzheimer's disease
(AD) detection, monitoring, and therapy since they are highly correlated with AD …

Advances in nanoprobes for molecular MRI of Alzheimer's disease

P Parekh, AA Badachhape, EA Tanifum… - Wiley …, 2024 - Wiley Online Library
Alzheimer's disease is the most common cause of dementia and a leading cause of mortality
in the elderly population. Diagnosis of Alzheimer's disease has traditionally relied on …

Metal complexes for the visualisation of amyloid peptides

JF Morfin, S Lacerda, CFGC Geraldes, É Tóth - Sensors & Diagnostics, 2022 - pubs.rsc.org
Amyloid forms of many different proteins have been long identified as relevant biomarkers in
important pathologies with high societal impact, including Aβ in Alzheimer's disease, amylin …

Rose bengal conjugated gadolinium complex as a new multimodal imaging agent targeting presynaptic vesicular glutamate transporters

S Kim, HK Kim, AR Baek, B Sung, BW Yang… - Journal of Industrial and …, 2021 - Elsevier
Glutamate is an important excitatory neurotransmitter, and vesicular glutamate transporters
(VGLUTs) are critical in regulating the extent of glutamate release. Because initial increase …