Glioblastoma multiforme (GBM), a grade IV astrocytoma, is the most common and deadly
type of primary malignant brain tumor, with a patient's median survival rate ranging from 15 …

Focal adhesion kinase (FAK) is a key regulator of growth factor receptor-and integrin-
mediated signals, governing fundamental processes in normal and cancer cells through its …

Abstract Src homology-2 (SH2) domain-containing phosphatases (Shps) are a small, highly
conserved subfamily of protein-tyrosine phosphatases, members of which are present in …

Critical roles for EPH receptor (EPH)–ephrin signalling in a range of chronic and
regenerative diseases are increasingly being recognized. In particular, the complex roles of …

Eph receptors constitute the largest family of tyrosine kinase receptors and, together with
their plasma-membrane-bound ephrin ligands, have many important functions during …

In the small intestine, the progeny of stem cells migrate in precise patterns. Absorptive,
enteroendocrine, and goblet cells migrate toward the villus while Paneth cells occupy the …

Here we show that cells lacking focal adhesion kinase (FAK) are refractory to motility signals
from platelet-derived and epidermal growth factors (PDGF and EGF respectively), and that …

Tyrosine phosphorylation is an important signalling mechanism in eukaryotic cells. In
cancer, oncogenic activation of tyrosine kinases is a common feature, and novel anticancer …

More than 25 years of research and preclinical validation have defined EphA2 receptor
tyrosine kinase as a promising molecular target for clinical translation in cancer treatment …

Both pro-and antioncogenic properties have been attributed to EphA2 kinase. We report that
a possible cause for this apparent paradox is diametrically opposite roles of EphA2 in …