Epidemiologic studies have, variably, shown the concomitant use of statin drugs to be
beneficial to cancer outcomes. Statin drugs have been FDA approved for three decades for …

The mevalonate synthesis inhibitors, statins, are mainstay therapeutics for cholesterol
management and cardiovascular health. Thirty years of research have uncovered supportive …

Statins are among the most commonly prescribed drugs, and around every fourth person
above the age of 40 is on statin medication. Therefore, it is of utmost clinical importance to …

Simple Summary This review delves into metabolic reprogramming in pancreatic cancer and
its development, with a special emphasis on the mevalonate pathway, encompassing …

Simple Summary Uveal melanoma is a rare and aggressive disease. Gα-proteins GNAQ
and GNA11 are driver mutations that activate MAP kinase and YAP/TAZ pathways. BAP1 …

We examined the impact of statins on Yes-associated Protein (YAP) localization,
phosphorylation and transcriptional activity in human and mouse pancreatic ductal …

Pre-clinical and retrospective studies of patients using statins to reduce plasma cholesterol
have suggested that statins may be useful to treat cancer. However, prospective clinical …

Background Statins are widely acknowledged for their application in patients with
hypercholesterolemia to reduce cardiovascular morbidity and mortality. More recently, their …

Simple Summary For tumors to initiate and sustain rapid growth, they need to alter their
metabolic reprograming to support this growth. While many oncogenes upregulate …

The hallmarks of tumor tissue are not only genetic aberrations but also the presence of
metabolic and oxidative stress as a result of hypoxia and lactic acidosis. The stress activates …