The prevalence of heart failure is on the rise and imposes a major health threat, in part, due
to the rapidly increased prevalence of overweight and obesity. To this point …

Cell death is a fundamental process in cardiac pathologies. Recent studies have revealed
multiple forms of cell death, and several of them have been demonstrated to underlie …

The global incidence of cardiac diseases is expected to increase in the coming years,
imposing a substantial socioeconomic burden on healthcare systems. Autophagy is a tightly …

Abstract Ischemia/reperfusion (I/R) of the heart leads to increased autophagic flux.
Preconditioning stimulates autophagic flux by AMPK and PI3-kinase activation and mTOR …

Rationale: Impaired autophagic flux contributes to ischemia/reperfusion (I/R)-induced
cardiomyocyte death, but the underlying molecular mechanisms remain largely unexplored …

Background Tumor necrosis factor-α (TNF-α) plays a central role in Alzheimer's disease
(AD) pathology, making biologic TNF-α inhibitors (TNFIs), including etanercept, viable …

Cardiomyocytes are large (∼ 40,000 µm3), rod-shaped muscle cells that provide the
working force behind each heartbeat. These highly structured cells are packed with dense …

Rationale: The ubiquitin-proteasome system (UPS) and the autophagic-lysosomal pathway
are pivotal to proteostasis. Targeting these pathways is emerging as an attractive strategy for …

Background Microglial activation-mediated neuroinflammation is a major contributor to early
brain injury (EBI) after subarachnoid hemorrhage (SAH). MicroRNA-124 (miR-124) is the …

Incomplete autophagy is an impaired self‐eating process of intracellular macromolecules
and organelles in which accumulated autophagosomes do not fuse with lysosomes for …