Methylation of cytosine in CpG dinucleotides and histone lysine and arginine residues is a
chromatin modification that critically contributes to the regulation of genome integrity …

Epigenetics governs a chromatin state regulatory system through five key mechanisms: DNA
modification, histone modification, RNA modification, chromatin remodeling, and non-coding …

SMNDC1 is a Tudor domain protein that recognizes di-methylated arginines and controls
gene expression as an essential splicing factor. Here, we study the specific contributions of …

UHRF1 facilitates the establishment and maintenance of DNA methylation patterns in
mammalian cells. The establishment domains are defined, including E3 ligase function, but …

Survival of motor neuron (SMN) functions in diverse biological pathways via recognition of
symmetric dimethylarginine (Rme2s) on proteins by its Tudor domain, and deficiency of …

NLRP3 is an intracellular sensor protein that causes inflammasome formation and
pyroptosis in response to a wide range of stimuli. Aberrant activation of NLRP3 …

Chromatin regulatory proteins are increasingly recognized as potential new drug targets.
Many of these proteins harbor one or more so called 'reader domains' that recognize …

Histone methylation reader domains are protein modules that recognize specific histone
methylation marks, such as methylated or unmethylated lysine or arginine residues on …

The Warburg effect‐related metabolic dysfunction of the tricarboxylic acid (TCA) cycle has
emerged as a hallmark of various solid tumors, particularly renal cell carcinoma (RCC). RCC …

In the last 40 years, cation− π interactions have become part of the lexicon of noncovalent
forces that drive protein binding. Indeed, tetraalkylammoniums are universally bound by …