Bone tissue is continuously remodeled through the concerted actions of bone cells, which
include bone resorption by osteoclasts and bone formation by osteoblasts, whereas …

Since the first description of the association between chronic kidney disease and heart
disease, many epidemiological studies have confirmed and extended this finding. As …

Importance Intravenous iron enables rapid correction of iron-deficiency anemia, but certain
formulations induce fibroblast growth factor 23–mediated hypophosphatemia. Objective To …

Hypoparathyroidism is a disease characterized by inadequately low circulating
concentrations of parathyroid hormone (PTH) resulting in low calcium levels and increased …

The portrait of osteoblasts and osteocytes has been subjected to a revision, since a large
body of evidence is attributing these cells amazing roles both inside and outside the bone …

Patients with chronic kidney disease (CKD) develop increased levels of the phosphate-
regulating hormone, fibroblast growth factor (FGF) 23, that are associated with a higher risk …

Cardiovascular disease is the leading cause of death in patients with chronic kidney disease
(CKD). As CKD progresses, CKD-specific risk factors, such as disordered mineral …

PTH and Vitamin D are two major regulators of mineral metabolism. They play critical roles
in the maintenance of calcium and phosphate homeostasis as well as the development and …

Chronic kidney disease (CKD) is a complex condition with a prevalence of 10–15%
worldwide. An inverse-graded relationship exists between cardiovascular events and …

Calcium (Ca2+) and phosphate (PO43−) homeostasis are coordinated by systemic and local
factors that regulate intestinal absorption, influx and efflux from bone, and kidney excretion …