Thanks to its safety and accessibility, magnetic resonance imaging (MRI) is extensively used
in clinical routine and research field, largely contributing to our understanding of the …

Hippocampal atrophy, as evidenced using magnetic resonance imaging (MRI), is one of the
most validated, easily accessible and widely used biomarkers of Alzheimer's disease (AD) …

Alzheimer's disease (AD) is a significant neocortical degenerative disorder characterized by
the progressive loss of neurons and secondary alterations in white matter tracts …

Alzheimer's disease (AD) is the leading cause of dementia in the United States and afflicts>
5.7 million Americans in 2018. Therapeutic options remain extremely limited to those that …

Background Two main genetic risks for sporadic Alzheimer's disease (AD) are a family
history and ɛ4 allele of apolipoprotein E. The brain and retina are part of the central nervous …

The goal of this review is to provide an overview of biomarkers for Alzheimer's disease (AD),
with emphasis on neuroimaging and cerebrospinal fluid (CSF) biomarkers. We first review …

Atrophy of the medial temporal lobe (MTL) occurs with aging, resulting in impaired episodic
memory. Aerobic fitness is positively correlated with total hippocampal volume, a heavily …

The ε4 allele of the apolipoprotein E (APOE4) is associated with an increased risk of
developing Alzheimer's disease (AD). Hence, several studies have compared the brain …

Cerebral blood flow (CBF) provides an indication of the metabolic status of the cortex and
may have utility in elucidating preclinical brain changes in persons at risk for Alzheimer's …

Presymptomatic studies in ALS have consistently captured considerable disease burden
long before symptom manifestation and contributed important academic insights. With the …