Ischemic stroke caused by arterial occlusion is the most common type of stroke, which is
among the most frequent causes of disability and death worldwide. Current treatment …

Alzheimer's disease (AD) is a typical progressive, chronic neurodegenerative disorder with
worldwide prevalence. Its clinical manifestation involves the presence of extracellular …

Lipoxygenase (5-LOX) inhibitors have been shown to be protective in several
neurodegenerative disease models; however, the underlying mechanisms remain unclear …

The polyphenols in fruits and vegetables may be partly responsible for the health‐promoting
effects attributed to fruit and vegetable intake. Although their properties have been relatively …

Oxidative stress and inflammatory response are important elements of Alzheimer's disease
(AD) pathogenesis, but the role of redox signaling cascade and its cross-talk with …

Ischemic stroke is a major cause of death and disability all over the world. Ischemic stroke
results from a temporary or permanent reduction of cerebral blood flow that leads to …

Introduction Innate immune cells play a role in modulating host immune response. Part of
the macrophage inflammatory response is the release of an array of inflammatory cytokines …

Macrophage polarization is critical to inflammation and resolution of inflammation. We
previously showed that high-mobility group box 1 (HMGB1) can engage receptor for …

Leukotrienes (LT) are a class of inflammatory mediators produced by the 5-lipoxygenase (5-
LO) enzyme from arachidonic acid (AA). We discussed the various LT inhibitors and …

Background Traumatic brain injury (TBI) is a major cause of preventable death and serious
morbidity in young adults. This complex pathological condition is characterized by significant …