Unveiling the Interplay of AMPK/SIRT1/PGC-1α axis in Brain Health: Promising Targets Against Aging and NDDs

PS Rakshe, BJ Dutta, S Chib, N Maurya… - Ageing Research Reviews, 2024 - Elsevier
The escalating prevalence of neurodegenerative diseases (NDDs) within an aging global
population presents a pressing challenge. The multifaceted pathophysiological mechanisms …

Safety and neuroprotective efficacy of palm oil and tocotrienol-rich fraction from palm oil: A systematic review

M Ismail, A Alsalahi, MU Imam, DJ Ooi, H Khaza'Ai… - Nutrients, 2020 - mdpi.com
Background: Several natural products have been reported to elicit beneficial effects against
neurodegenerative disorders due to their vitamin E contents. However, the neuroprotective …

Biophysical insight into the anti-fibrillation potential of Glyburide for its possible implication in therapeutic intervention of amyloid associated diseases

S Malik, MK Siddiqi, N Naseem, F Nabi, A Masroor… - Biochimie, 2023 - Elsevier
Protein aggregation is an underlying cause of many neurodegenerative diseases. Also, the
overlapping pathological disturbances between neurodegenerative diseases and type-2 …

Health Benefits of Palm Tocotrienol-Rich Fraction: A Systematic Review of Randomized Controlled Trials

AD Looi, UD Palanisamy, M Moorthy… - Nutrition …, 2025 - academic.oup.com
Context Vitamin E, a well-known antioxidant with numerous positive effects on human
health, encompasses tocotrienol-rich fraction (TRF), a natural variant abundant in palm oil …

Alterations of the glutamatergic system in diabetes mellitus

M Hristov, A Nankova, P Andreeva-Gateva - Metabolic Brain Disease, 2024 - Springer
Diabetes mellitus (DM) is a chronic disease characterized by elevated blood glucose levels
caused by a lack of insulin production (type 1 diabetes) or insulin resistance (type 2 …

[HTML][HTML] Associations Between Diabetes Mellitus and Neurodegenerative Diseases

L Szablewski - International Journal of Molecular Sciences, 2025 - mdpi.com
Diabetes mellitus (DM) and neurodegenerative diseases/disturbances are worldwide health
problems. The most common chronic conditions diagnosed in persons 60 years and older …

Investigating metabolic characteristics of type 2 diabetes mellitus-related cognitive dysfunction and correlating therapeutic effects of Di Dang Tang in animal models

C Sheng, R Yue - Journal of Ethnopharmacology, 2025 - Elsevier
Abstract Ethnopharmacological relevance: Di Dang Tang is a classic formula from Shang
Han Lun, originally used to treat conditions such as blood stasis and heat accumulation. It is …

CaMKIV/CREB/BDNF signaling pathway expression in prefrontal cortex, amygdala, hippocampus and hypothalamus in streptozotocin-induced diabetic mice with …

C Espasandín, S Rivero, L Bengoa, K Cal… - Experimental Brain …, 2022 - Springer
Individuals with diabetes mellitus (DM) tend to manifest anxiety and depression, which could
be related to changes in the expression of calcium/calmodulin-dependent protein kinase IV …

Stem Cell Therapy for the Treatment of Parkinson's Disease: What Promise Does it Hold?

A Nasrolahi, Z Shabani… - Current Stem Cell …, 2024 - ingentaconnect.com
Parkinson's disease (PD) is a common, progressive neurodegenerative disorder
characterized by substantia nigra dopamine cell death and a varied clinical picture that …

The Role of Antioxidant on Health and Age-Related Diseases in Aging

BL Tan, ME Norhaizan, BL Tan… - The Role of Antioxidants in …, 2021 - Springer
Substantial studies have suggested that natural compounds rich in antioxidants can
enhance the immune system and decrease oxidative stress. These substances facilitate in …