Ca 2+ ions are key second messengers in both excitable and non-excitable cells. Owing to
the rather pleiotropic nature of Ca 2+ transporters and other Ca 2+-binding proteins …

The divalent cation calcium (Ca2+) is considered one of the main second messengers
inside cells and acts as the most prominent signal in a plethora of biological processes. Its …

Mitochondrial calcium uniporter (MCU) has an important role in regulating mitochondrial
calcium (Ca2+) homeostasis. Dysregulation of mitochondrial Ca2+ homeostasis has been …

Pharmacological targeting of mitochondrial ion channels is emerging as a promising
approach to eliminate cancer cells; as most of these channels are differentially expressed …

Several drug targets have been amenable to drug discovery pursuit not until the
characterization of the mitochondrial permeability transition pore (MPTP), a pore with an …

Mitochondria are bioenergetic organelles with a plethora of fundamental functions ranging
from metabolism and ATP production to modulation of signaling events leading to cell …

MICU 1 is a mitochondrial inner membrane protein that inhibits mitochondrial calcium entry;
elevated MICU 1 expression is characteristic of many cancers, including ovarian cancer …

Food availability represents a major worldwide concern due to climate change and
population growth. Low-temperature stress (LTS) severely restricts the growth of tomato …

Aberrations in mitochondrial Ca2+ homeostasis have been associated with different
pathological conditions, including neurological defects, cardiovascular diseases, and, in the …

Osteoporosis is a disorder of bone metabolism that is extremely common in elderly patients
as well as in postmenopausal women. The main manifestation is that the bone resorption …