Immunogenic cell stress and death
Dying mammalian cells emit numerous signals that interact with the host to dictate the
immunological correlates of cellular stress and death. In the absence of reactive antigenic …
immunological correlates of cellular stress and death. In the absence of reactive antigenic …
SARS-CoV-2 biology and host interactions
The zoonotic emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
and the ensuing coronavirus disease 2019 (COVID-19) pandemic have profoundly affected …
and the ensuing coronavirus disease 2019 (COVID-19) pandemic have profoundly affected …
Evolution and neutralization escape of the SARS-CoV-2 BA. 2.86 subvariant
Abstract Omicron BA. 2.86 subvariant differs from Omicron BA. 2 as well as recently
circulating variants by over 30 mutations in the spike protein alone. Here we report on the …
circulating variants by over 30 mutations in the spike protein alone. Here we report on the …
SARS-CoV-2 NSP5 and N protein counteract the RIG-I signaling pathway by suppressing the formation of stress granules
Y Zheng, J Deng, L Han, MW Zhuang, Y Xu… - Signal transduction and …, 2022 - nature.com
As a highly pathogenic human coronavirus, SARS-CoV-2 has to counteract an intricate
network of antiviral host responses to establish infection and spread. The nucleic acid …
network of antiviral host responses to establish infection and spread. The nucleic acid …
Inhibition of PKR by Viruses
T Cesaro, T Michiels - Frontiers in microbiology, 2021 - frontiersin.org
Cells respond to viral infections through sensors that detect non-self-molecules, and through
effectors, which can have direct antiviral activities or adapt cell physiology to limit viral …
effectors, which can have direct antiviral activities or adapt cell physiology to limit viral …
[HTML][HTML] SARS-CoV-2 nucleocapsid protein binds host mRNAs and attenuates stress granules to impair host stress response
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nucleocapsid (N) protein is
essential for viral replication, making it a promising target for antiviral drug and vaccine …
essential for viral replication, making it a promising target for antiviral drug and vaccine …
Epigallocatechin gallate inhibits the uridylate-specific endoribonuclease Nsp15 and efficiently neutralizes the SARS-CoV-2 strain
S Hong, SH Seo, SJ Woo, Y Kwon… - Journal of Agricultural …, 2021 - ACS Publications
SARS-CoV-2, the coronavirus strain that initiated the COVID-19 pandemic, and its
subsequent variants present challenges to vaccine development and treatment. As the …
subsequent variants present challenges to vaccine development and treatment. As the …
Characterization of SARS2 Nsp15 nuclease activity reveals it's mad about U
Nsp15 is a uridine specific endoribonuclease that coronaviruses employ to cleave viral RNA
and evade host immune defense systems. Previous structures of Nsp15 from across …
and evade host immune defense systems. Previous structures of Nsp15 from across …
[HTML][HTML] Time-resolved proteomic profiling reveals compositional and functional transitions across the stress granule life cycle
S Hu, Y Zhang, Q Yi, C Yang, Y Liu, Y Bai - Nature Communications, 2023 - nature.com
Stress granules (SGs) are dynamic, membrane-less organelles. With their formation and
disassembly processes characterized, it remains elusive how compositional transitions are …
disassembly processes characterized, it remains elusive how compositional transitions are …
Arginine methylation of SARS-Cov-2 nucleocapsid protein regulates RNA binding, its ability to suppress stress granule formation, and viral replication
Viral proteins are known to be methylated by host protein arginine methyltransferases
(PRMTs) necessary for the viral life cycle, but it remains unknown whether severe acute …
(PRMTs) necessary for the viral life cycle, but it remains unknown whether severe acute …