Spreading depolarizations (SDs) are classically thought to be associated with spreading
depression of cortical activity. Here, we found that SDs in patients with subarachnoid …

Abstract Development of epilepsy or epileptogenesis promotes recurrent seizures. As of
today, there are no effective prophylactic therapies to prevent the onset of epilepsy …

Background The term “aura” refers to a well-defined pattern of usually positive, progressive,
and reversible neurological symptoms, with spreading depolarization as the underlying …

Homocysteine is a sulfur-containing endogenous amino acid leading to neurotoxic effects at
high concentrations. Population studies suggest an association between plasma …

The development of ischemic lesions has primarily been studied in horizontal cortical space.
However, how ischemic lesions develop through the cortical depth remains largely …

Epidemiological data suggest that elevated homocysteine is associated with migraine with
aura. However, how homocysteine contributes to migraine is still unclear. Here, we tested …

Objective. The development of experimental methodology utilizing graphene micro-
transistor arrays to facilitate and advance translational research into cortical spreading …

Objective Cortical spreading depolarization (SD) and seizures are often co‐occurring
electrophysiological phenomena. However, the cross‐layer dynamics of SD during seizures …

Hyperhomocysteinemia (hHCY) is a metabolic disorder characterized by elevated levels of
homocysteine in plasma. hHCY correlates with a high risk of migraine headaches …

Brain ischemia induces slow voltage shifts in the cerebral cortex, including waves of
spreading depolarization (SD) and negative ultraslow potentials (NUPs), which are …