MicroRNA profiling: approaches and considerations
CC Pritchard, HH Cheng, M Tewari - Nature Reviews Genetics, 2012 - nature.com
MicroRNAs (miRNAs) are small RNAs that post-transcriptionally regulate the expression of
thousands of genes in a broad range of organisms in both normal physiological contexts …
thousands of genes in a broad range of organisms in both normal physiological contexts …
Genetic variation in microRNA networks: the implications for cancer research
Many studies have highlighted the role that microRNAs have in physiological processes and
how their deregulation can lead to cancer. More recently, it has been proposed that the …
how their deregulation can lead to cancer. More recently, it has been proposed that the …
miRDeep2 accurately identifies known and hundreds of novel microRNA genes in seven animal clades
MR Friedländer, SD Mackowiak, N Li… - Nucleic acids …, 2012 - academic.oup.com
Abstract microRNAs (miRNAs) are a large class of small non-coding RNAs which post-
transcriptionally regulate the expression of a large fraction of all animal genes and are …
transcriptionally regulate the expression of a large fraction of all animal genes and are …
tRNA-derived fragments (tRFs): emerging new roles for an ancient RNA in the regulation of gene expression
SP Keam, G Hutvagner - Life, 2015 - mdpi.com
This review will summarise the recent discoveries and current state of research on short
noncoding RNAs derived from tRNAs—known as tRNA-derived fragments (tRFs). It will …
noncoding RNAs derived from tRNAs—known as tRNA-derived fragments (tRFs). It will …
Deep sequencing of small RNAs from human skin reveals major alterations in the psoriasis miRNAome
Psoriasis is a chronic and complex inflammatory skin disease with lesions displaying
dramatically altered mRNA expression profiles. However, much less is known about the …
dramatically altered mRNA expression profiles. However, much less is known about the …
Biogenesis of mammalian microRNAs by a non-canonical processing pathway
MA Havens, AA Reich, DM Duelli… - Nucleic acids …, 2012 - academic.oup.com
Canonical microRNA biogenesis requires the Microprocessor components, Drosha and
DGCR8, to generate precursor-miRNA, and Dicer to form mature miRNA. The …
DGCR8, to generate precursor-miRNA, and Dicer to form mature miRNA. The …
The miRNA profile of human pancreatic islets and beta-cells and relationship to type 2 diabetes pathogenesis
Recent advances in the understanding of the genetics of type 2 diabetes (T2D) susceptibility
have focused attention on the regulation of transcriptional activity within the pancreatic beta …
have focused attention on the regulation of transcriptional activity within the pancreatic beta …
The role of miR‐378a in metabolism, angiogenesis, and muscle biology
B Krist, U Florczyk… - International journal …, 2015 - Wiley Online Library
MicroRNA‐378a (miR‐378a, previously known as miR‐378) is one of the small noncoding
RNA molecules able to regulate gene expression at posttranscriptional level. Its two mature …
RNA molecules able to regulate gene expression at posttranscriptional level. Its two mature …
Whole-genome sequencing identifies a recurrent functional synonymous mutation in melanoma
JJ Gartner, SCJ Parker, TD Prickett… - Proceedings of the …, 2013 - National Acad Sciences
Synonymous mutations, which do not alter the protein sequence, have been shown to affect
protein function [Sauna ZE, Kimchi-Sarfaty C (2011) Nat Rev Genet 12 (10): 683–691] …
protein function [Sauna ZE, Kimchi-Sarfaty C (2011) Nat Rev Genet 12 (10): 683–691] …
Melanoma cell invasiveness is regulated by miR‐211 suppression of the BRN2 transcription factor
To identify microRNAs potentially involved in melanomagenesis, we compared microRNA
expression profiles between melanoma cell lines and cultured melanocytes. The most …
expression profiles between melanoma cell lines and cultured melanocytes. The most …