Abstract Cyclin-dependent kinase 4 (CDK4) and CDK6 are critical mediators of cellular
transition into S phase and are important for the initiation, growth and survival of many …

Mammalian cells encode three D cyclins (D1, D2, and D3) that coordinately function as
allosteric regulators of cyclin-dependent kinase 4 (CDK4) and CDK6 to regulate cell cycle …

Cyclin D1 is one of the most important oncoproteins that drives cancer cell proliferation and
associates with tamoxifen resistance in breast cancer. Here, we identify a lncRNA, DILA1 …

The cell cycle is tightly regulated by cyclins and their catalytic moieties, the cyclin-dependent
kinases (CDKs). Cyclin D1, in association with CDK4/6, acts as a mitogenic sensor and …

Cyclin D1, and to a lesser extent the other D-type cyclins, is frequently deregulated in cancer
and is a biomarker of cancer phenotype and disease progression. The ability of these …

F-box proteins, which are the substrate-recognition subunits of SKP1–cullin 1–F-box protein
(SCF) E3 ligase complexes, have pivotal roles in multiple cellular processes through …

E3 ligases confer specificity to ubiquitination by recognizing target substrates and mediating
transfer of ubiquitin from an E2 ubiquitin-conjugating enzyme to substrate. The activity of …

Most cancers preserve functional retinoblastoma (Rb) and may, therefore, respond to
inhibition of D-cyclin-dependent Rb kinases, CDK4 and CDK6. To date, CDK4/6 inhibitors …

Research over the past quarter century has identified cyclin D-dependent kinases, CDK4
and CDK6, as the major oncogenic drivers among members of the CDK superfamily …

Two families of E3 ubiquitin ligases are prominent in cell cycle regulation and mediate the
timely and precise ubiquitin–proteasome-dependent degradation of key cell cycle proteins …