An increasing number of patients worldwide suffers from chronic kidney disease (CKD).
CKD is accompanied by kidney fibrosis, which affects all compartments of the kidney, ie, the …

Diseases of the heart and the kidney, including heart failure and chronic kidney disease, can
dramatically impair life expectancy and the quality of life of patients. The heart and kidney …

Rejection remains the main cause of premature graft loss after kidney transplantation,
despite the use of potent immunosuppression. This highlights the need to better understand …

Chronic allograft dysfunction (CAD), characterized histologically by interstitial fibrosis and
tubular atrophy, is the major cause of kidney allograft loss. Here, using single nuclei RNA …

Although decades of the reductionist approach achieved great milestones in optimizing the
immunosuppression therapy, traditional clinical parameters still fail in predicting both acute …

Abstract Interferon-γ (IFN-γ) is an important cytokine in tissue homeostasis and immune
response, while studies about it in antibody-mediated rejection (ABMR) are very limited. This …

The kidney epithelium, with its intricate arrangement of highly specialized cell types,
constitutes the functional core of the organ. Loss of kidney epithelium is linked to the loss of …

Abstract RNA-sequencing (RNA-seq) is a technique to determine the order of nucleotides in
an RNA segment. Modern sequencing platforms simultaneously sequence millions of RNA …

The Banff classification is regularly updated to integrate recent advances in the
characterization of kidney allograft rejection, gathering novel diagnostic, prognostic, and …

Histologic and molecular features of antibody-mediated rejec... : Current Opinion in Organ
Transplantation Histologic and molecular features of antibody-mediated rejection : Current …