[HTML][HTML] Artemisinin-based combination therapy (ACT) and drug resistance molecular markers: A systematic review of clinical studies from two malaria endemic …

A Arya, LPK Foko, S Chaudhry, A Sharma… - International Journal for …, 2021 - Elsevier
Artemisinin-based combination therapies (ACT) are currently used as a first-line malaria
therapy in endemic countries worldwide. This systematic review aims at presenting the …

Novel pfkelch13 Gene Polymorphism Associates With Artemisinin Resistance in Eastern India

S Das, S Manna, B Saha, AK Hati… - Clinical Infectious …, 2019 - academic.oup.com
Background Artesunate-sulfadoxine-pyrimethamine (ASSP) is the frontline artemisinin
combination therapy (ACT) in India. Random, irrational, subtherapeutic artemisinin doses …

Artemisinin combination therapy fails even in the absence of Plasmodium falciparum kelch13 gene polymorphism in Central India

S Das, A Kar, S Manna, S Mandal, S Mandal, S Das… - Scientific reports, 2021 - nature.com
Artemisinin is the frontline fast-acting anti-malarial against P. falciparum. Emergence and
spread of resistant parasite in eastern-India poses a threat to national malaria control …

Genetic Variations Associated with Drug Resistance Markers in Asymptomatic Plasmodium falciparum Infections in Myanmar

Y Zhao, Z Liu, MT Soe, L Wang, TN Soe, H Wei, A Than… - Genes, 2019 - mdpi.com
The emergence and spread of drug resistance is a problem hindering malaria elimination in
Southeast Asia. In this study, genetic variations in drug resistance markers of Plasmodium …

Plasmodium falciparum multidrug resistance gene-1 polymorphisms in Northern Nigeria: implications for the continued use of artemether-lumefantrine in the region

A Adamu, MS Jada, HMS Haruna, BO Yakubu… - Malaria Journal, 2020 - Springer
Background The analysis of single nucleotide polymorphism (SNPs) in drug-resistance
associated genes is a commonly used strategy for the surveillance of anti-malarial drug …

Effects of Drug Policy Changes on Evolution of Molecular Markers of Plasmodium falciparum Resistance to Chloroquine, Amodiaquine, and Sulphadoxine …

MN Moyeh, DL Njimoh, MS Evehe, IM Ali… - Malaria Research …, 2018 - Wiley Online Library
Background. As a result of the spread of parasites resistant to antimalarial drugs, Malaria
treatment guidelines in Cameroon evolved from nonartemisinin monotherapy to artemisinin …

Molecular mutation profile of pfcrt in Plasmodium falciparum isolates imported from Africa in Henan province

R Zhou, H Zhang, C Yang, Y Liu, Y Zhao, S Li, D Qian… - Malaria Journal, 2016 - Springer
Background Anti-malarial drug resistance is a primary public health problem. Haplotypes of
pfcrt gene have been implicated to be molecular markers of chloroquine (CQ) resistance …

Genomic characterization of Plasmodium falciparum genes associated with anti-folate drug resistance and treatment outcomes in eastern India: A molecular …

S Das, S Tripathy, A Das, MK Sharma, A Nag… - Frontiers in Cellular …, 2022 - frontiersin.org
Introduction After being used vigorously for the previous two decades to treat P. falciparum,
chloroquine and sulfadoxine-pyrimethamine were replaced in 2009 with an artemisinin …

Characterization of drug resistance genes in Indian Plasmodium falciparum and Plasmodium vivax field isolates

G Narang, J Jakhan, S Tamang, K Yadav, V Singh - Acta Tropica, 2024 - Elsevier
One of the major challenges for malaria control and elimination is the spread and
emergence of antimalarial drug resistance. Mutations in Plasmodium falciparum (Pf) and …

[HTML][HTML] Synergism between Pfcrt and Pfmdr1 genes could account for the slow recovery of chloroquine sensitive Plasmodium falciparum strains in Ghana after …

KK Asare, JN Boampong, NO Duah, R Afoakwah… - Journal of infection and …, 2017 - Elsevier
Unlike other countries, the chloroquine resistant marker Pfcrt T76 mutant has remained fairly
stable in Ghana several years after official disuse of chloroquine. Certain mutations in …