Antibiotic-resistant Mycobacterium tuberculosis strains are threatening progress in
containing the global tuberculosis epidemic. Mycobacterium tuberculosis is intrinsically …

Current tuberculosis (TB) drug development efforts are not sufficient to end the global TB
epidemic. Recent efforts have focused on the development of whole-cell screening assays …

Decaprenylphosphoryl-β-d-ribose 2′-epimerase (DprE1), a vital enzyme for cell wall
synthesis, plays a crucial role in the formation of lipoarabinomannan and arabinogalactan. It …

The Tuberculosis Drug Accelerator, an experiment designed to facilitate collaboration in
tuberculosis drug discovery by breaking down barriers among competing labs and …

Two parallel revolutions were born in the golden era of antibiotics (~ 1940 to 1960). One
was a revolution in medicine as physicians went to war with microbes. The second was a …

The rising incidence of antimicrobial resistance (AMR) makes it imperative to understand the
underlying mechanisms. Mycobacterium tuberculosis (Mtb) is the single leading cause of …

The genus Mycobacterium comprises a group of obligately aerobic bacteria that have
adapted to inhabit a wide range of intracellular and extracellular environments …

Mycobacterium tuberculosis is the cause of tuberculosis (TB), a disease which continues to
overwhelm health systems in endemic regions despite the existence of effective combination …

We report two series of novel cephalosporins that are bactericidal to Mycobacterium
tuberculosis alone of the pathogens tested, which only kill M. tuberculosis when its …

The dormant phenotype acquired by Mycobacterium tuberculosis during infection poses a
major challenge in disease treatment, since these bacilli show tolerance to front-line drugs …