Local anesthetics have been used clinically for more than a century, but new insights into
their mechanisms of action and their interaction with biological systems continue to surprise …

EditordAnaesthetists, general practitioners, surgeons, and dentists use local anaesthetics
(LA) in their daily practice. Insufficient analgesic effect may result from various causes …

Despite successfully utilizing anesthetics for over 150 years, the mechanism of action
remains relatively unknown. Recent studies have shown promising results, but due to the …

Background: Genetic interindividual variability is associated with adverse drug reactions
(ADRs) and affects the response to common drugs used in anesthesia. Despite their …

The report of anesthetic technique failure is crucial and the etiology of the problem should
be determined. We describe a case of locoregional anesthesia failure, in which, after …

Objective Although cardiac sympathetic denervation (CSD) effectively manages refractory
ventricular tachyarrhythmias (RVTs) in long-QT syndrome and catecholaminergic …

Eine 55-jährige Patientin stellt sich wegen einer bevorstehenden dringlichen perkutanen
transluminalen Angioplastie (PTA) aufgrund einer endometriosebedingten Stenose der A …

Figure 1. JODHPUR TECHNIQUE (JT)-Depiction of recipient site preparation of stable
lesions of vitiligo.(A) Baseline clinical image of the lesions over the patient's abdomen …

Introduction Patient resistance to local anesthetics is rarely considered as the cause of
regional anesthesia failure. Case report We report a case of resistance to local anesthetics …

Background Local anesthetic (LA) resistance is an exceedingly rare phenomenon.
Incidence is unknown given the rarity of disease. Often, inadequate response to LA can be …