Phosphodiesterase-4 (PDE4), mainly present in immune cells, epithelial cells, and brain
cells, manifests as an intracellular non-receptor enzyme that modulates inflammation and …

Cyclic nucleotide phosphodiesterases 4 (PDE4) are a family of enzymes which specifically
promote the hydrolysis and degradation of cAMP. The inhibition of PDE4 enzymes has been …

Background and Purpose Ulcerative colitis (UC) is an aetiologically refractory inflammatory
disease, accompanied by dysfunction of the epithelial barrier and intestinal inflammation …

Objective. Vitronectin (VTN) has been reported to trigger cell pyroptosis to aggravate
inflammation in our previous study. However, the function of VTN in inflammatory bowel …

The pathogenesis of ulcerative colitis (UC), a chronic intestine inflammatory disease
primarily affecting adolescents, remains uncertain. Contemporary studies suggest that a …

Abstract Inflammatory Bowel Diseases (IBDs) are chronic disorders with iterative intestinal
mucosal inflammation which remain unmet medical needs. PDE4 inhibitors were reported to …

If the observed long-term efficacy and safety are confirmed in clinical trials, oral roflumilast
may represent a novel and favourable treatment option for patients with plaque psoriasis …

The biological cascade of second messenger–cyclic adenosine monophosphate (cAMP)–as
a molecular mechanism implicated in memory and learning regulation has captured the …

Abstract Ethnopharmacological relevance Hypericum sampsonii Hance (Yuanbaocao), a
traditional herbal medicine with various pharmacological properties, is traditionally used to …

OBJECTIVE: To investigate the efficacy of Qingchi San (青赤散, QCS), a preparation of
Traditional Chinese Medicine, on ulcerative colitis (UC) in mice by inhibiting the …