Covering: up to June 2020 Ribosomally-synthesized and post-translationally modified
peptides (RiPPs) are a large group of natural products. A community-driven review in 2013 …

Many oxidation–reduction (redox) enzymes, particularly oxygenases, have roles in reactions
that make and break C–C bonds. The list includes cytochrome P450 and other heme-based …

The threat of antibiotic resistant bacterial infections continues to underscore the need for
new treatment options. Historically, small molecule metabolites from microbes have …

As an endogenous neuroprotectant agent, adenosine is extensively distributed and is
particularly abundant in the central nervous system (CNS). Under physiological conditions …

Thiopeptides (also known as thiazolyl peptides) are structurally complex natural products
with rich biological activities. Known for over 70 years for potent killing of Gram-positive …

Nature harnesses the unique properties of cysteinyl radical intermediates for a diverse
range of essential biological transformations including DNA biosynthesis and repair …

HemN is a radical S‐adenosyl‐l‐methionine (SAM) enzyme that catalyzes the oxidative
decarboxylation of coproporphyrinogen III to produce protoporphyrinogen IX, an …

Thiazole-containing pyritides (thiopeptides) are ribosomally synthesized and post-
translationally modified peptides (RiPPs) that have attracted interest owing to their potent …

Methyl coenzyme M reductase (MCR) catalyzes the last step in the biological production of
methane by methanogenic archaea, as well as the first step in the anaerobic oxidation of …

Cyclopropanation of unactivated olefinic bonds via addition of a reactive one-carbon
species is well developed in synthetic chemistry, whereas natural cyclopropane …