Abstract Topoisomerase IB (Top1), a subcategory of DNA topoisomerase enzymes is
expressed much higher in several tumor cells. Therefore, modulating the activity of Top1 in …

It is a well-known phenomenon that natural products can serve as powerful drug leads to
generate new molecular entities with novel therapeutic utility. Evodiamine (Evo), a major …

The Lassa virus (LASV), an RNA virus prevalent in West and Central Africa, causes severe
hemorrhagic fever with a high fatality rate. However, no FDA-approved treatments or …

Evodiamine has many biological activities. Herein, we synthesize 23 disubstituted
derivatives of N14-phenyl or the E-ring of evodiamine and conduct systematic structure …

Natural product evodiamine is one of the most privileged scaffolds in drug discovery and is
suitable for derivatization, which can be conducted quickly for structure optimization and …

Gastrointestinal tumor is an important factor threatening human health. Natural product-
based drug discovery is a popular paradigm for expanding the chemical space and …

Evodiamine (EVO) is a natural quinolone alkaloid firstly isolated from the fruit of Evodia
rutaecarpa, which is one of the most frequently used traditional Chinese herb for treating a …

Evodiamine (EVO) is a quinazoline carboline alkaloid isolated from the fruits of the
traditional Chinese herb Evodiae fructus. In the present study, we synthesized thirty EVO …

The heat shock protein (HSP) system is essential for the conformational stability and function
of several proteins. Therefore, the development of efficacious HSP-targeting anticancer …

Introduction: Human topoisomerase 1 (TOP1) is an important target of various anticancer
compounds. The design and discovery of inhibitors targeting TOP1 are of great significance …