One-component systems dominate signal transduction in prokaryotes
Two-component systems that link environmental signals to cellular responses are viewed as
the primary mode of signal transduction in prokaryotes. By analyzing information encoded …
the primary mode of signal transduction in prokaryotes. By analyzing information encoded …
Bioinformatical approaches to characterize intrinsically disordered/unstructured proteins
Intrinsically disordered/unstructured proteins exist without a stable three-dimensional (3D)
structure as highly flexible conformational ensembles. The available genome sequences …
structure as highly flexible conformational ensembles. The available genome sequences …
MYRF is a membrane-associated transcription factor that autoproteolytically cleaves to directly activate myelin genes
H Bujalka, M Koenning, S Jackson, VM Perreau… - PLoS …, 2013 - journals.plos.org
The myelination of axons is a crucial step during vertebrate central nervous system (CNS)
development, allowing for rapid and energy efficient saltatory conduction of nerve impulses …
development, allowing for rapid and energy efficient saltatory conduction of nerve impulses …
Origin and Spread of de Novo Genes in Drosophila melanogaster Populations
Comparative genomic analyses have revealed that genes may arise from ancestrally
nongenic sequence. However, the origin and spread of these de novo genes within …
nongenic sequence. However, the origin and spread of these de novo genes within …
Cache domains that are homologous to, but different from PAS domains comprise the largest superfamily of extracellular sensors in prokaryotes
AA Upadhyay, AD Fleetwood, O Adebali… - PLoS computational …, 2016 - journals.plos.org
Cellular receptors usually contain a designated sensory domain that recognizes the signal.
Per/Arnt/Sim (PAS) domains are ubiquitous sensors in thousands of species ranging from …
Per/Arnt/Sim (PAS) domains are ubiquitous sensors in thousands of species ranging from …
Molecular characterization revealed the role of thaumatin-like proteins of bread wheat in stress response
Thaumatin-like proteins (TLPs) are related to pathogenesis-related-5 (PR-5) family and
involved in stress response. Herein, a total of 93 TLP genes were identified in the genome of …
involved in stress response. Herein, a total of 93 TLP genes were identified in the genome of …
AggreProt: a web server for predicting and engineering aggregation prone regions in proteins
J Planas-Iglesias, S Borko, J Swiatkowski… - Nucleic Acids …, 2024 - academic.oup.com
Recombinant proteins play pivotal roles in numerous applications including industrial
biocatalysts or therapeutics. Despite the recent progress in computational protein structure …
biocatalysts or therapeutics. Despite the recent progress in computational protein structure …
Charged residues next to transmembrane regions revisited:“Positive-inside rule” is complemented by the “negative inside depletion/outside enrichment rule”
Abstract Background Transmembrane helices (TMHs) frequently occur amongst protein
architectures as means for proteins to attach to or embed into biological membranes …
architectures as means for proteins to attach to or embed into biological membranes …
LEM2 is a novel MAN1-related inner nuclear membrane protein associated with A-type lamins
A Brachner, S Reipert, R Foisner… - Journal of cell …, 2005 - journals.biologists.com
The LEM (lamina-associated polypeptide–emerin–MAN1) domain is a motif shared by a
group of lamin-interacting proteins in the inner nuclear membrane (INM) and in the …
group of lamin-interacting proteins in the inner nuclear membrane (INM) and in the …
The ring between ring fingers (RBR) protein family
Proteins of the ring between ring fingers (RBR)-domain family are characterized by three
groups of specifically clustered (typically eight) cysteine and histidine residues. Whereas the …
groups of specifically clustered (typically eight) cysteine and histidine residues. Whereas the …