Premature activation of digestive enzymes in the pancreas has been linked to development
of pancreatitis for more than a century. Recent development of novel models to study the …

Despite the potential of whole-genome sequencing (WGS) to improve patient diagnosis and
care, the empirical value of WGS in the cancer genetics clinic is unknown. We performed …

Background Genetic predisposition in paediatric idiopathic acute, acute recurrent
pancreatitis and its consequences are unknown. We studied frequency of genetic markers in …

Background The zinc finger protein A20 is an important negative regulator of inflammation;
polymorphisms in the corresponding gene, TNFAIP3, have been reported to be associated …

La pancreatitis aguda (PA) y la pancreatitis aguda recurrente (PAR) son enfermedades cuya
incidencia aparentemente va en incremento. A pesar de la creciente evidencia sobre el …

Acute pancreatitis (AP) and recurrent acute pancreatitis (RAP) are conditions, whose
incidence is apparently on the rise. Despite the ever-increasing evidence regarding the …

Abstract Background and Aims Acute pancreatitis (AP) is a severe pancreatic disorder that
remains associated with high mortality due to a lack of effective drugs and management …

Background: There are important inter-individual variations in the incidence and severity of
acute pancreatitis in patients with severe hypertriglyceridemia. Several genes involved in …

This comprehensive meta-analysis was applied to case-control studies of the association
between pancreatitis and PRSS1 gene to assess the joint evidence for the association, the …

Context Hereditary pancreatitis is typically caused by the PRSS1 R122H or N29I mutations
resulting in high penetrance (about 80%) autosomal dominant disorder that is usually …