Recent trends in pharmaceutical analysis to foster modern drug discovery by comparative in-silico profiling of drugs and related substances

SB Ganorkar, Y Vander Heyden - TrAC Trends in Analytical Chemistry, 2022 - Elsevier
Pharmaceutical drug analysis (PDA), besides quantifying drugs and related substances
(RS), can enrich drug discovery (DD) by suggesting new leads. PDA may be extended …

Whiteness and greenness assessment with efficacy evaluation of two UPLC systems applied for the quantification of cinnarizine and dimenhydrinate along with their …

EM Morgan, HM Lotfy, RH Obaydo, YM Fayez… - Sustainable Chemistry …, 2023 - Elsevier
Fixed-dose combination of cinnarizine (CIN) and dimenhydrinate (DMH) is an effective
therapy for patients diagnosed for having central and/or peripheral vestibular disorder …

ChlorTox scale assessment, greenness, and whiteness evaluation of selective spectrophotometric analysis of dimenhydrinate and cinnarizine

EM Morgan, YM Fayez, SA Boltia, RH Obaydo… - … Acta Part A: Molecular …, 2024 - Elsevier
Nausea and vomiting are considered common series side effects induced by chemotherapy
treatment in cancer patients. This annoying side effect can impair the patient's compliance to …

1-Benzhydryl-piperazine: Isolation, structure determination, and in silico studies for a novel potential narcotic agent detected in sports supplements

Z Arslan, E Okuroğlu, H Şenol, Z Türkmen - Journal of Food Composition …, 2024 - Elsevier
Adulteration of sports supplements poses significant health risks, necessitating stringent
regulatory oversight. This study investigates deceptive practices by manufacturers, including …

Green analytical chemistry metrics and life-cycle assessment approach to analytical method development

MM Abdelrahman - Green chemical analysis and sample preparations …, 2022 - Springer
The environmental consequences of chemical and analytical research, particularly the use
and production of toxic reagents and solvents, have sparked widespread concern …

Ecofriendly appraisal of stability‐indicating high‐performance chromatographic assay of canagliflozin and metformin with their toxic impurities; in silico toxicity …

RA Emam, AA Emam - Journal of separation science, 2023 - Wiley Online Library
Canagliflozin is an oral hypoglycemic drug recently formulated in combination with a
biguanide, metformin hydrochloride, for improving its hypoglycemic action. Canagliflozin has …

Experimentally designed chromatographic method for the simultaneous analysis of dimenhydrinate, cinnarizine and their toxic impurities

FH Edrees, AS Saad, MT Alsaadi, NH Amin… - RSC …, 2021 - pubs.rsc.org
Recently, experimental design has beaten the traditional optimization approach (one
variable at a time) by providing better quality for chromatographic separation using minimal …

Access to Diarylmethanol Skeletons via a Samarium/Copper-Mediated Sequential Three-Component C–H Functionalization Reaction

B Song, D Zhang, S Xiao, C Liu, H Chen… - The Journal of Organic …, 2021 - ACS Publications
A novel three-component reaction was developed via a one-pot strategy for the construction
of diarylmethanol esters by using a halobenzene and an ester in N, N-dimethylformamide …

A sensitive LC-MS/MS method for the determination of potential genotoxic impurities in Cinnarizine

S Mullangi, K Ravindhranath, MR Yarala… - Annales …, 2023 - Elsevier
Summary A highly sensitive LC–MS/MS method for the trace level determination of
genotoxic impurities, Cinnamyl chloride and Benzhydryl chloride, in Cinnarizine drug …

Green Electrochemical Sensing: Novel Ion-Selective Electrode Method for Precise Determination of Dimenhydrinate and its Metabolite along with Cinnarizine in …

SA Boltia, EM Morgan, RH Obaydo… - Journal of The …, 2024 - iopscience.iop.org
Green and sustainable scientific research is crucial for health and environmental
improvement. Electrochemical analysis simplifies complex processes, saving time and cost …