Shifting mutational constraints in the SARS-CoV-2 receptor-binding domain during viral evolution
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has evolved variants with
substitutions in the spike receptor-binding domain (RBD) that affect its affinity for angiotensin …
substitutions in the spike receptor-binding domain (RBD) that affect its affinity for angiotensin …
[HTML][HTML] Molecular basis of receptor binding and antibody neutralization of Omicron
Q Hong, W Han, J Li, S Xu, Y Wang, C Xu, Z Li, Y Wang… - Nature, 2022 - nature.com
Abstract The SARS-CoV-2 Omicron variant exhibits striking immune evasion and is
spreading rapidly worldwide. Understanding the structural basis of the high transmissibility …
spreading rapidly worldwide. Understanding the structural basis of the high transmissibility …
[HTML][HTML] Structural basis for SARS-CoV-2 Delta variant recognition of ACE2 receptor and broadly neutralizing antibodies
Abstract The SARS-CoV-2 Delta variant is currently the dominant circulating strain in the
world. Uncovering the structural basis of the enhanced transmission and altered immune …
world. Uncovering the structural basis of the enhanced transmission and altered immune …
[HTML][HTML] Mechanism and evolution of human ACE2 binding by SARS-CoV-2 spike
AG Wrobel - Current Opinion in Structural Biology, 2023 - Elsevier
Spike glycoprotein of SARS-CoV-2 mediates viral entry into host cells by facilitating virus
attachment and membrane fusion. ACE2 is the main receptor of SARS-CoV-2 and its …
attachment and membrane fusion. ACE2 is the main receptor of SARS-CoV-2 and its …
[HTML][HTML] Omicron SARS-CoV-2 mutations stabilize spike up-RBD conformation and lead to a non-RBM-binding monoclonal antibody escape
Z Zhao, J Zhou, M Tian, M Huang, S Liu, Y Xie… - Nature …, 2022 - nature.com
Omicron SARS-CoV-2 is rapidly spreading worldwide. To delineate the impact of emerging
mutations on spike's properties, we performed systematic structural analyses on apo …
mutations on spike's properties, we performed systematic structural analyses on apo …
[HTML][HTML] Structural plasticity and immune evasion of SARS-CoV-2 spike variants
The global pandemic of COVID-19 caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) has significantly affected every human life and overloaded the …
coronavirus 2 (SARS-CoV-2) has significantly affected every human life and overloaded the …
Structural insights into the binding of SARS-CoV-2, SARS-CoV, and hCoV-NL63 spike receptor-binding domain to horse ACE2
Severe acute respiratory syndrome coronavirus (SARS-CoV), SARS-CoV-2, and human
coronavirus (hCoV)-NL63 utilize ACE2 as the functional receptor for cell entry, which leads …
coronavirus (hCoV)-NL63 utilize ACE2 as the functional receptor for cell entry, which leads …
Tuning DNA Dissociation from Spherical Nucleic Acids for Enhanced Immunostimulation
The stability of the core can significantly impact the therapeutic effectiveness of liposome-
based drugs. While the spherical nucleic acid (SNA) architecture has elevated liposomal …
based drugs. While the spherical nucleic acid (SNA) architecture has elevated liposomal …
Mapping cross-variant neutralizing sites on the SARS-CoV-2 spike protein
The emergence of multiple severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
variants of concern threatens the efficacy of currently approved vaccines and authorized …
variants of concern threatens the efficacy of currently approved vaccines and authorized …
Spatial-and valence-matched neutralizing DNA nanostructure blocks wild-type SARS-CoV-2 and Omicron variant infection
S Wan, S Liu, M Sun, J Zhang, X Wei, T Song, Y Li… - ACS …, 2022 - ACS Publications
Natural ligand–receptor interactions that play pivotal roles in biological events are ideal
models for design and assembly of artificial recognition molecules. Herein, aiming at the …
models for design and assembly of artificial recognition molecules. Herein, aiming at the …