Anaphylaxis is a severe, acute, life-threatening multisystem allergic reaction resulting from
the release of a plethora of mediators from mast cells culminating in serious respiratory …

Studies with mouse models demonstrate 2 pathways of systemic anaphylaxis: a classic
pathway mediated by IgE, FcɛRI, mast cells, histamine, and platelet-activating factor (PAF) …

Control of blood vessel tone is central to vascular homeostasis. Here we show that
metabolism of tryptophan to kynurenine by indoleamine 2, 3-dioxygenase (Ido) expressed in …

BACKGROUND: Platelet-activating factor (PAF) is an important mediator and correlates with
anaphylaxis severity. How well PAF correlates with severity relative to histamine or tryptase …

The endothelium is essential for the maintenance of vascular homeostasis. Central to this
role is the production of endothelium-derived nitric oxide (EDNO), synthesized by the …

Mast cells have long been recognized for their role in the genesis of allergic inflammation;
and more recently for their participation in innate and acquired immune responses. Mast …

The class II α-isoform of phosphatidylinositol 3-kinase (PI3K-C2α) is localized in
endosomes, the trans-Golgi network and clathrin-coated vesicles; however, its functional …

To cite this article: Ben‐Shoshan M, Clarke AE. Anaphylaxis: past, present and future.
Allergy 2011; 66: 1–14. Abstract Anaphylaxis is a clinical emergency, and recent reports …

Anaphylaxis is a systemic reaction involving multiple organ systems, but it is believed that it
may be influenced by cellular events in mast cells and basophils resulting in the release of …

Anaphylaxis is a serious allergic reaction that can be rapid in onset and occasionally fatal.
This is a review of the literature on the epidemiology of anaphylaxis, diagnostic criteria …