Cognitive impairment in schizophrenia: aetiology, pathophysiology, and treatment

RA McCutcheon, RSE Keefe, PK McGuire - Molecular psychiatry, 2023 - nature.com
Cognitive deficits are a core feature of schizophrenia, account for much of the impaired
functioning associated with the disorder and are not responsive to existing treatments. In this …

Hot and cold executive functions in the brain: A prefrontal-cingular network

MA Salehinejad, E Ghanavati… - Brain and …, 2021 - journals.sagepub.com
Executive functions, or cognitive control, are higher-order cognitive functions needed for
adaptive goal-directed behaviours and are significantly impaired in majority of …

[HTML][HTML] COVID-19 vaccination for people with severe mental illness: why, what, and how?

V Mazereel, K Van Assche, J Detraux… - The Lancet …, 2021 - thelancet.com
Psychiatric disorders, and especially severe mental illness, are associated with an
increased risk of severe acute respiratory syndrome coronavirus 2 infection and COVID-19 …

Validity and utility of hierarchical taxonomy of psychopathology (HiTOP): I. Psychosis superspectrum

R Kotov, KG Jonas, WT Carpenter, MN Dretsch… - World …, 2020 - Wiley Online Library
The Hierarchical Taxonomy of Psychopathology (HiTOP) is a scientific effort to address
shortcomings of traditional mental disorder diagnoses, which suffer from arbitrary …

Neuroinflammation in schizophrenia: the role of nuclear factor kappa B

CE Murphy, AK Walker, CS Weickert - Translational psychiatry, 2021 - nature.com
Neuroinflammation, particularly in the dorsolateral prefrontal cortex, is well-established in a
subset of people with schizophrenia, with significant increases in inflammatory markers …

[HTML][HTML] Cognitive dysfunction in schizophrenia: an expert group paper on the current state of the art

PD Harvey, M Bosia, R Cavallaro, OD Howes… - Schizophrenia Research …, 2022 - Elsevier
Cognitive impairment in schizophrenia represents one of the main obstacles to clinical and
functional recovery. This expert group paper brings together experts in schizophrenia …

The effect of antipsychotics on the cognitive performance of individuals with psychotic disorders: network meta-analyses of randomized controlled trials

DP Baldez, TB Biazus, FD Rabelo-da-Ponte… - Neuroscience & …, 2021 - Elsevier
Cognitive deficits are a core aspect of psychotic disorders; however, it is not clear to which
extent different pharmacological treatments could distinctly impact these outcomes. Hence …

COVID-19-related mortality risk in people with severe mental illness: a systematic and critical review

M De Hert, V Mazereel, M Stroobants… - Frontiers in …, 2022 - frontiersin.org
Background: Increasing clinical evidence suggests that people with severe mental illness
(SMI), including schizophrenia spectrum disorders, bipolar disorder (BD), and major …

Schizophrenia: a disorder of broken brain bioenergetics

ND Henkel, X Wu, SM O'Donovan, EA Devine… - Molecular …, 2022 - nature.com
A substantial and diverse body of literature suggests that the pathophysiology of
schizophrenia is related to deficits of bioenergetic function. While antipsychotics are an …

Cognitive impairment associated with schizophrenia: from pathophysiology to treatment

DC Javitt - Annual Review of Pharmacology and Toxicology, 2023 - annualreviews.org
Cognitive impairment is a core feature of schizophrenia and a major contributor to poor
functional outcomes. Methods for assessment of cognitive dysfunction in schizophrenia are …