Several studies implicate dysregulation of the ADAMTS-13/VWF axis as playing a major role
in vaso-occlusive events (VOE) in SCD. Another highlight is reducing iron overload, which …

The pathophysiology of SCD is multifaceted, as it involves systemwide vascular activation,
altered blood rheology, and the activation of immune responses and coagulative pathways …

Previous studies have reported elevated von Willebrand factor (VWF) levels in patients with
sickle cell disease (SCD) and demonstrated a key role for the VWF-ADAMTS13 axis in the …

A hypercoagulable state, chronic inflammation, and increased risk of venous thrombosis and
stroke are prominent features in patients with sickle cell disease (SCD). Coagulation factor …

Sickle cell disease (SCD) is a hereditary hemoglobinopathy marked by hemolytic anemia
and vaso-occlusive events (VOEs). Chronic endothelial activation, inflammation, and …

An excessive von Willebrand factor (VWF) secretion, coupled with a moderate to severe
deficiency of ADAMTS13 activity, serves as a linking mechanism between inflammation to …

The root cause of sickle cell disease (SCD) has been known for nearly a century, however,
few therapies to treat the disease are available. Over several decades of work, with …

Although it is caused by a single-nucleotide mutation in the β-globin gene, sickle cell
anemia (SCA) is a systemic disease with complex, incompletely elucidated pathologies. The …

Sickle cell disease (SCD) is the most common inherited blood disorder, and it affects
millions of people worldwide. In SCD, the primary event is polymerization of abnormal …

Sickle Cell Disease (SCD) is the most prevalent inherited monogenic disease worldwide,
caused by a single nucleotide mutation in the gene for beta-globin. This results in an …