Alzheimer disease (AD) is a heterogeneous disease with a complex pathobiology. The
presence of extracellular β-amyloid deposition as neuritic plaques and intracellular …

Novel targets to arrest neurodegeneration in several dementing conditions involving
misfolded protein accumulations may be found in the diverse signaling pathways of the …

Converging evidence continues to point towards Tau aggregation and pathology formation
as central events in the pathogenesis of Alzheimer's disease and other Tauopathies …

Neurodegenerative disorders of ageing (NDAs) such as Alzheimer disease, Parkinson
disease, frontotemporal dementia, Huntington disease and amyotrophic lateral sclerosis …

Autophagy is a conserved pathway that delivers cytoplasmic contents to the lysosome for
degradation. Here we consider its roles in neuronal health and disease. We review …

Tau is well established as a microtubule-associated protein in neurons. However, under
pathological conditions, aberrant assembly of tau into insoluble aggregates is accompanied …

Alzheimer's disease acknowledged as progressive multifarious neurodegenerative disorder,
is the leading cause of dementia in late adult life. Pathologically it is characterized by …

Frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) are fatal
neurodegenerative disorders that are thought to exist on a clinical and pathological …

The pathway leading from soluble and monomeric to hyperphosphorylated, insoluble and
filamentous tau protein is at the centre of many human neurodegenerative diseases …

Lowering total tau levels is an attractive therapeutic strategy for Alzheimer's disease and
other tauopathies. High-throughput screening in neurons derived from human induced …