Tuberous sclerosis complex is a rare genetic disease associated with mutations in the TSC1
or TSC2 genes, which cause overactivation of the mTOR complex. In the past 5 years …

Epileptogenesis in infants with tuberous sclerosis complex (TSC) is a gradual and dynamic
process, leading to early onset and difficult-to-treat seizures. Several cellular, molecular and …

Fetal, infant, and toddler neuroimaging is commonly thought of as a development of modern
times (last two decades). Yet, this field mobilized shortly after the discovery and …

Mutations in TSC1 or TSC2 genes are linked to alterations in neuronal function which
ultimately lead to the development of a complex neurological phenotype. Here we review …

Background: Epilepsy affects 70–90% of patients with tuberous sclerosis complex (TSC). In
one-third of them, the seizures become refractory to treatment. Drug-resistant epilepsy …

Numerous studies showed that epilepsy represents a high burden in Tuberous Sclerosis
Complex (TSC), affecting 63 to 78% of the patients. Epilepsy will be refractory to medication …

Objective Tuberous sclerosis complex (TSC) is a genetic disease that arises from TSC1 or
TSC2 abnormalities and induces the overactivation of the mammalian/mechanistic target of …

BACKGROUND AND PURPOSE: Strong emphasis has been placed recently on early (4
postnatal months) detection of tuberous sclerosis complex and the introduction of …

Tuberous Sclerosis Complex (TSC), is a neurocutaneous disorder, associated with a high
prevalence of autism spectrum disorder (ASD;∼ 50% of individuals). As TSC is a leading …

ABSTRACT Introduction Developmental and Epileptic Encephalopathies (DEEs)
encompass a group of neurological disorders caused by either abnormal neuronal …