Maternal hypothyroidism: An overview of current experimental models

M Ghanbari, A Ghasemi - Life sciences, 2017 - Elsevier
Maternal hypothyroidism (MH) is the most common cause of transient congenital
hypothyroidism. Different animal models are used for assessing developmental effects of …

Hypothyroidism causes endoplasmic reticulum stress in adult rat hippocampus: a mechanism associated with hippocampal damage

AP Torres-Manzo, M Franco-Colín… - Oxidative medicine …, 2018 - Wiley Online Library
Thyroid hormones (TH) are essential for hippocampal neuronal viability in adulthood, and
their deficiency causes hypothyroidism, which is related to oxidative stress events and …

Similar distribution changes of GABAergic interneuron subpopulations in contrast to the different impact on neurogenesis between developmental and adult-stage …

A Shiraki, H Akane, T Ohishi, L Wang, R Morita… - Archives of …, 2012 - Springer
Hypothyroidism affects neurogenesis. The present study was performed to clarify the
sensitivity of neurogenesis-related cellular responses in the hippocampal dentate gyrus …

Maternal thyroid hormone deficiency during gestation and lactation alters metabolic and thyroid programming of the offspring in the adult stage

J Tapia-Martínez, AP Torres-Manzo… - Hormone and …, 2019 - thieme-connect.com
Environmental stimuli during critical developmental stages establish long-term physiological
and structural patterns that “program” health during adult life. Little is known about how …

Early postnatal hypothyroidism reduces juvenile play behavior, but prenatal hypothyroidism compensates for these effects

KV Northcutt, TS Leal-Medina, YS Yoon - Physiology & Behavior, 2021 - Elsevier
Perinatal hypothyroidism causes long-lasting effects on behavior, including hyperactivity,
cognitive delays/deficits, and a reduction in anxiety. Although there is some evidence that …

[HTML][HTML] Hypothyroid offspring replacement with euthyroid wet nurses during lactation improves thyroid programming without modifying metabolic programming

J Tapia-Martínez, M Franco-Colín… - … of Endocrinology and …, 2019 - SciELO Brasil
Objective Determine the milk quality effect during lactation on the metabolic and thyroid
programming of hypothyroid offspring. Materials and methods Ten-week-old female Wistar …

The joint effect of congenital hypothyroidism and hypercaloric diet consumption as triggers of type 2 diabetes mellitus

JA Tapia-Martínez, M Franco-Colín… - European Thyroid …, 2022 - etj.bioscientifica.com
Introduction Congenital hypothyroidism affects metabolic and thyroid programming, having a
deleterious effect on bodyweight regulation promoting metabolic diseases. This work aimed …

The pattern of thalamocortical and brain stem projections to the vibrissae–related sensory and motor cortices in de-whiskered congenital hypothyroid rats

MR Afarinesh, G Behzadi - Metabolic brain disease, 2017 - Springer
The present study is designed to investigate the plastic organization of the thalamo-cortical
(TC) and brain stem afferents of whisker primary sensory (wS1) and motor (wM1) cortical …

Effects of maternal hypothroidism during preganacy on anxiety-like behaviors in adulthood rats: Impact of moderate treadmill exercise

Z Ghaffari, AA Vafaei, A li Rashidy-Pour… - koomesh, 2016 - brieflands.com
: Introduction: Previous study indicated that the lack of thyroid hormones during brain
development can be associated with structural and biochemical changes in the brain that …

Levothyroxine therapy attenuates anxiety-like states induced by mild chronically of neonatal hypothyroidism in both male and female rats

M Taheri, MR Afarinesh, GH Meftahi, A Karimi… - Toxin …, 2021 - Taylor & Francis
Subclinical hypothyroidism tends to be more prevalent due to having a deficiency in iodine
intake, which could lead to it. The role of sex differentiation in the susceptibility for anxiety …