Endolymph, the extracellular solution in cochlea, contains 150 mM K+ and exhibits a
potential of approximately+ 80 mV relative to neighboring extracellular spaces. This unique …

Normal development, function and repair of the sensory epithelia in the inner ear are all
dependent on gap junctional intercellular communication. Mutations in the connexin genes …

Defects in several different connexins have been associated with several different diseases.
The most common of these is deafness, where a few mutations in connexin (Cx) 26 have …

Tight junctions, gap junctions, adherens junctions, and desmosomes represent intricate
structural intercellular channels and bridges that are present in several tissues, including …

Gap junctions allow the exchange of ions and small molecules between adjacent cells
through intercellular channels formed by connexin proteins, which can also form functional …

Consanguineous Pakistani pedigrees segregating deafness have contributed decisively to
the discovery of 31 of the 68 genes associated with nonsyndromic autosomal recessive …

Mutations in genes encoding gap‐and tight‐junction proteins have been shown to cause
distinct forms of hearing loss. We have now determined the GJB2 [connexin 26 (Cx26)] …

The human and mouse genomes contain 21 and 20 connexin genes, respectively. During
the last 10-year period, genetic research on connexins has been stimulated by two parallel …

Oculodentodigital dysplasia (ODDD) and Hallermann‐Streiff syndrome (HSS) share several
clinical characteristics. However, while ODDD is a dominantly inherited disorder due to …

The expression of multiple connexin (Cx) types in the epidermis, their differential expression
during wound closure and the association of skin pathology with specific Cx gene mutations …