The aim of this review is to give an outline of the blood clearance function of the liver
sinusoidal endothelial cells (LSECs) in health and disease. Lining the hundreds of millions …

Elderly adults constitute a rapidly growing part of the global population, thus resulting in an
increase in morbidity and mortality related to cardiovascular disease (CVD), which remains …

The heterogeneity of endothelial cells (ECs) across tissues remains incompletely
inventoried. We constructed an atlas of> 32,000 single-EC transcriptomes from 11 mouse …

Lipid nanoparticles (LNPs) are the leading nonviral technologies for the delivery of
exogenous RNA to target cells in vivo. As systemic delivery platforms, these technologies …

Extracellular vesicles (EVs) are released by most cell types but providing evidence for their
physiological relevance remains challenging due to a lack of appropriate model organisms …

Up to 99% of systemically administered nanoparticles are cleared through the liver. Within
the liver, most nanoparticles are thought to be sequestered by macrophages (Kupffer cells) …

The decline in the fisheries of traditional marine species has been an incentive for the
diversification of today's aquaculture sector into the intensive rearing of many finfish species …

Necrosis is an overarching term that describes cell death modalities caused by (extreme)
adverse conditions in which cells lose structural integrity. A guaranteed consequence of …

The liver sinusoidal endothelial cell (LSEC) forms the fenestrated wall of the hepatic
sinusoid and functions as a control post regulating and surveying the trafficking of molecules …

To maintain homeostasis, the animal body is equipped with a powerful system to remove
circulating waste. This review presents evidence that the scavenger endothelial cell (SEC) is …