Over the past 25 years, successive cloning of SLC34A1, SLC34A2 and SLC34A3, which
encode the sodium-dependent inorganic phosphate (Pi) cotransport proteins 2a–2c, has …

The SLC34 family of sodium-driven phosphate cotransporters comprises three members:
NaPi-IIa (SLC34A1), NaPi-IIb (SLC34A2), and NaPi-IIc (SLC34A3). These transporters …

Idiopathic infantile hypercalcemia (IIH) is characterized by severe hypercalcemia with failure
to thrive, vomiting, dehydration, and nephrocalcinosis. Recently, mutations in the vitamin D …

Pathogenic variants in solute carrier family 34, member 3 (SLC34A3), the gene encoding the
sodium-dependent phosphate cotransporter 2c (NPT2c), cause hereditary …

Phosphate plays essential biological roles and its plasma level in humans requires tight
control to avoid bone loss (insufficiency) or vascular calcification (excess). Intestinal …

The expression cloning some 25 years ago of the first member of SLC34 solute carrier
family, the renal sodium-coupled inorganic phosphate cotransporter (NaPi-IIa) from rat and …

Abstract Background Variants in SLC34A2 encoding the sodium-dependent phosphate
transport protein 2b (NaPi-IIb) cause the rare lung disease pulmonary alveolar microlithiasis …

Progress towards understanding the molecular mechanisms of phosphate homeostasis
through sodium-dependent transmembrane uptake has long been stymied by the absence …

Transporters of the SLC34 family (NaPi-IIa, b, c) catalyze uptake of inorganic phosphate (P i)
in renal and intestinal epithelia. The transport cycle requires three Na+ ions and one …

New Findings What is the central question of this study? The opossum kidney (OK) cell line
is the main in vitro model of proximal tubular Pi transport, but it is incomplete because only …