Over the last two decades, hydrogen sulfide (H2S) has emerged as an endogenous
regulator of a broad range of physiological functions. H2S belongs to the class of molecules …

Preeclampsia (PE) is a multifactorial pregnancy disease, characterized by new-onset
gestational hypertension with (or without) proteinuria or end-organ failure, exclusively …

Dysfunction of the endothelial lining of lesion-prone areas of the arterial vasculature is an
important contributor to the pathobiology of atherosclerotic cardiovascular disease …

Background: Current paradigms suggest that nitric oxide (NO) produced by endothelial cells
(ECs) through endothelial nitric oxide synthase (eNOS) in the vessel wall is the primary …

Nitric oxide (NO), the smallest signalling molecule known, is produced by three isoforms of
NO synthase (NOS; EC 1.14. 13.39). They all utilize l-arginine and molecular oxygen as …

Proper brain function depends on neurovascular coupling: neural activity rapidly increases
local blood flow to meet moment-to-moment changes in regional brain energy demand …

Endothelial cells are a constitutive part of the heart and vasculature and form a crucial link
between the cardiovascular system and the immune system. Besides their commonly …

Studies of nitric oxide over the past two decades have highlighted the fundamental
importance of gaseous signaling molecules in biology and medicine. The physiological role …

Preeclampsia is a pregnancy-specific hypertensive syndrome that causes substantial
maternal and fetal morbidity and mortality. Maternal endothelial dysfunction mediated by …

Endothelial nitric oxide synthase (eNOS) is the nitric oxide synthase isoform responsible for
maintaining systemic blood pressure, vascular remodelling and angiogenesis,,,. eNOS is …