Significance: Iron accumulation occurs in the central nervous system (CNS) in a variety of
neurological conditions as diverse as spinal cord injury, stroke, multiple sclerosis …

Inflammation is a primary component of the central nervous system injury response.
Traumatic brain and spinal cord injury are characterized by a pronounced microglial …

This study investigated the role of the complement activation fragment C5a in secondary
pathology following contusive spinal cord injury (SCI). C5ar−/− mice, which lack the …

Macrophages in the injured spinal cord originate from resident microglia and blood
monocytes. Whether this diversity in origins contributes to their seemingly dual role in …

Background: Degenerative cervical myelopathy (DCM) manifests as the primary cause of
spinal cord dysfunction and is non-traumatic, chronic and progressive in nature …

Background The acute phase response (APR) to CNS insults contributes to the overall
magnitude and nature of the systemic inflammatory response. Aspects of this response are …

Iron accumulation in the CNS occurs in many neurological disorders. It can contribute to
neuropathology as iron is a redox-active metal that can generate free radicals. The reasons …

This study examined the sensitivity of ultra-high field (16.4 T) diffusion tensor imaging (DTI;
70 μm in-plane resolution, 1 mm slice thickness) to evaluate the spatiotemporal …

Prognosis and treatment evaluation of spinal cord injury (SCI) are still in the long-term
research stage. Prognostic factors for SCI treatment need effective biomarker to assess …

Purpose Adequate evaluation of spinal cord parenchyma and accurate identification of
injury range are considered two premises for the research and treatment of chronic spinal …