Pre-eclampsia: pathophysiology and clinical implications

GJ Burton, CW Redman, JM Roberts, A Moffett - Bmj, 2019 - bmj.com
Pre-eclampsia is a common disorder that particularly affects first pregnancies. The clinical
presentation is highly variable but hypertension and proteinuria are usually seen. These …

Combining biomarkers to predict pregnancy complications and redefine preeclampsia: the angiogenic-placental syndrome

H Stepan, M Hund, T Andraczek - Hypertension, 2020 - Am Heart Assoc
Placental dysfunction underlies a spectrum of perinatal pathologies, including preeclampsia
and fetal growth restriction. Angiogenesis-related factors, including sFlt-1 (soluble fms-like …

[HTML][HTML] Oxidative stress and mitochondrial dysfunction in early-onset and late-onset preeclampsia

R Marín, DI Chiarello, C Abad, D Rojas… - … et Biophysica Acta (BBA …, 2020 - Elsevier
Preeclampsia is a pregnancy-specific syndrome with multisystem involvement which leads
to foetal, neonatal, and maternal morbidity and mortality. This syndrome is characterized by …

Mechanisms of endothelial dysfunction in pre-eclampsia and gestational diabetes mellitus: windows into future cardiometabolic health?

CJ McElwain, E Tuboly, FP McCarthy… - Frontiers in …, 2020 - frontiersin.org
Placental insufficiency and adipose tissue dysregulation are postulated to play key roles in
the pathophysiology of both pre-eclampsia (PE) and gestational diabetes mellitus (GDM). A …

The prediction of early preeclampsia: Results from a longitudinal proteomics study

AL Tarca, R Romero, N Benshalom-Tirosh, NG Than… - PloS one, 2019 - journals.plos.org
Objectives To identify maternal plasma protein markers for early preeclampsia (delivery< 34
weeks of gestation) and to determine whether the prediction performance is affected by …

Prediction models for preeclampsia: A systematic review

AC De Kat, J Hirst, M Woodward, S Kennedy… - Pregnancy …, 2019 - Elsevier
Background Preeclampsia is a disease specific to pregnancy that can cause severe
maternal and foetal morbidity and mortality. Early identification of women at higher risk for …

The prediction of late-onset preeclampsia: Results from a longitudinal proteomics study

O Erez, R Romero, E Maymon, P Chaemsaithong… - PloS one, 2017 - journals.plos.org
Background Late-onset preeclampsia is the most prevalent phenotype of this syndrome;
nevertheless, only a few biomarkers for its early diagnosis have been reported. We sought to …

The ROBINS‐I and the NOS had similar reliability but differed in applicability: a random sampling observational studies of systematic reviews/meta‐analysis

Y Zhang, L Huang, D Wang, P Ren… - Journal of Evidence …, 2021 - Wiley Online Library
Objective There is a lack of evidence on the usage of the quality assessment tool‐the Risk
Of Bias In Nonrandomized Studies‐of Interventions (ROBINS‐I). This article aimed to …

Predictive value of the sFlt-1/PlGF ratio in women with suspected preeclampsia: An update

A Velegrakis, E Kouvidi… - International …, 2023 - spandidos-publications.com
Preeclampsia (PE) is a major complication of pregnancy with an incidence rate of 2-8% and
is a leading cause of maternal mortality and morbidity. The various consequences of severe …

[HTML][HTML] Evaluation of sFlt-1/PlGF ratio for predicting and improving clinical management of pre-eclampsia: Experience in a specialized perinatal care center

H Caillon, C Tardif, E Dumontet… - Annals of laboratory …, 2018 - synapse.koreamed.org
Background Management of pregnant women at high risk of pre-eclampsia (PE) requires
frequent monitoring, with referral to specialized perinatal care centers. Reliable tests are …