Natural nonproteinogenic amino acids vastly outnumber the well-known 22 proteinogenic
amino acids. Such amino acids are generated in specialized metabolic pathways. In these …

We report that l-threonine may substitute for l-serine in the β-substitution reaction of an
engineered subunit of tryptophan synthase from Pyrococcus furiosus, yielding (2 S, 3 S)-β …

This review provides an overview of different C 1 building blocks as substrates of enzymes,
or part of their cofactors, and the resulting functionalized products. There is an emphasis on …

Tryptophan synthase (TrpS) catalyzes the final steps in the biosynthesis of l-tryptophan from
l-serine (Ser) and indole-3-glycerol phosphate (IGP). We report that native TrpS can also …

Herein, we report an effective multi-component synthesis that starts with readily available
starting materials and accesses poly-substituted pyridine derivatives by using L-proline as a …

β-Carboline (βC) alkaloids constitute a large family of indole alkaloids that exhibit diverse
pharmacological properties, such as antitumor, antiviral, antiparasitic, and antimicrobial …

The β-carboline alkaloids are a large group of natural and synthetic indole alkaloids with
various pharmacological properties. Previously, the gene cluster of streptonigrin …

Streptonigrin (STN, 1) is a highly functionalized aminoquinone alkaloid antibiotic with broad
and potent antitumor activity. Previous isotope-labelling and genetic studies suggested that …

Xantholipin is a polycyclic xanthone antibiotic that exhibits potent cytotoxic and antibacterial
activity. In this study, a new xanthone-type antibiotic, xantholipin B (1), was isolated for the …

Cryptococcus neoformans is an important human pathogen with limited options for
treatments. We have interrogated extracts from fungal fermentations to find Cryptococcus …