Primate embryogenesis predicts the hallmarks of human naïve pluripotency
T Boroviak, J Nichols - Development, 2017 - journals.biologists.com
Naïve pluripotent mouse embryonic stem cells (ESCs) resemble the preimplantation epiblast
and efficiently contribute to chimaeras. Primate ESCs correspond to the postimplantation …
and efficiently contribute to chimaeras. Primate ESCs correspond to the postimplantation …
Epigenetic differences between naïve and primed pluripotent stem cells
It has been 8 years since the concept of naïve and primed pluripotent stem cell states was
first proposed. Both are states of pluripotency, but exhibit slightly different properties. The …
first proposed. Both are states of pluripotency, but exhibit slightly different properties. The …
[HTML][HTML] Single-cell landscape of transcriptional heterogeneity and cell fate decisions during mouse early gastrulation
H Mohammed, I Hernando-Herraez, A Savino… - Cell reports, 2017 - cell.com
The mouse inner cell mass (ICM) segregates into the epiblast and primitive endoderm (PrE)
lineages coincident with implantation of the embryo. The epiblast subsequently undergoes …
lineages coincident with implantation of the embryo. The epiblast subsequently undergoes …
Open chromatin, epigenetic plasticity, and nuclear organization in pluripotency
S Schlesinger, E Meshorer - Developmental Cell, 2019 - cell.com
Pluripotent embryonic stem cells (ESCs) are considered to have open and accessible
chromatin relative to differentiated cells. However, as many studies supporting these …
chromatin relative to differentiated cells. However, as many studies supporting these …
Genes that escape from X‐chromosome inactivation: Potential contributors to Klinefelter syndrome
MJ Navarro‐Cobos, BP Balaton… - American Journal of …, 2020 - Wiley Online Library
One of the two X chromosomes in females is epigenetically inactivated, thereby
compensating for the dosage difference in X‐linked genes between XX females and XY …
compensating for the dosage difference in X‐linked genes between XX females and XY …
Overcoming autocrine FGF signaling-induced heterogeneity in naive human ESCs enables modeling of random X chromosome inactivation
Primed and naive human embryonic stem cells (hESCs) do not fully recapitulate the X
chromosome status observed in human preimplantation epiblast and fail to initiate random X …
chromosome status observed in human preimplantation epiblast and fail to initiate random X …
Modeling unveils sex differences of signaling networks in mouse embryonic stem cells
For a short period during early development of mammalian embryos, both X chromosomes
in females are active, before dosage compensation is ensured through X‐chromosome …
in females are active, before dosage compensation is ensured through X‐chromosome …
Allele-specific RNA imaging shows that allelic imbalances can arise in tissues through transcriptional bursting
Extensive cell-to-cell variation exists even among putatively identical cells, and there is great
interest in understanding how the properties of transcription relate to this heterogeneity …
interest in understanding how the properties of transcription relate to this heterogeneity …
A system to analyze the initiation of random X-chromosome inactivation using time-lapse imaging of single cells
In female eutherian mammal development, X-chromosome inactivation (XCI) of one of the
two X chromosomes is initiated early. Understanding the relationship between the initiation …
two X chromosomes is initiated early. Understanding the relationship between the initiation …
The SWI/SNF ATP-dependent chromatin remodeling complex in cell lineage priming and early development
D Saha, S Animireddy… - Biochemical Society …, 2024 - portlandpress.com
ATP dependent chromatin remodelers have pivotal roles in transcription, DNA replication
and repair, and maintaining genome integrity. SWI/SNF remodelers were first discovered in …
and repair, and maintaining genome integrity. SWI/SNF remodelers were first discovered in …