Currently, cancer ranks as the second leading cause of death worldwide, and at the same
time, the burden of cancer continues to increase. The underlying molecular pathways …

Advances in the understanding of the Tribbles family of pseudokinases (TRIB1, TRIB2 and
TRIB3) reveal these proteins as potentially valuable biomarkers of disease diagnosis …

The approval of the first kinase inhibitor, Gleevec, ushered in a paradigm shift for
oncological treatment—the use of genomic data for targeted, efficacious therapies. Since …

Background Kidney renal clear cell carcinoma (KIRC) is the most frequently diagnosed
subtype of renal cell carcinoma (RCC); however, the pathogenesis and diagnostic …

Background Hypoxic pulmonary hypertension (PH) is a refractory pulmonary vascular
remodeling disease, and the efficiency of current PH treatment strategies is unsatisfactory …

Simple Summary Accumulating evidence supports a key function for Tribbles proteins in
oncogenesis, both in leukemia and solid tumors. However, the exact role of these proteins is …

TRIB3 roles in tumor progression have been revealed with similar or opposite results. Here,
we found that TRIB3 expression was highly expressed in lung cancer tissues and correlated …

Abstract Interleukin (IL-6) is a pleotropic cytokine with both tumor-promoting and-inhibitory
effects on breast cancer growth. However, the mechanisms governing the outcome of IL-6 …

TP53 is a classic tumor suppressor, but its role in kidney cancer remains unclear. In our
study, we tried to explain the role of p53 in kidney cancer through the p53-related enhancer …

Fast-developing single-cell technologies create unprecedented opportunities to reveal cell
heterogeneity and diversity. Accurate classification of single cells is a critical prerequisite for …