Background Dental caries is a chronic, multifactorial and biofilm-mediated oral bacterial
infection affecting almost every age group and every geographical region. Streptococcus …

Vitamin B6 is a designation for the six vitamers pyridoxal, pyridoxine, pyridoxamine,
pyridoxal 5′-phosphate (PLP), pyridoxine 5′-phosphate, and pyridoxamine. PLP, being …

The B6 vitamer pyridoxal 5′-phosphate (PLP) is a co-factor for proteins and enzymes that
are involved in diverse cellular processes. Therefore, PLP is essential for organisms from all …

Pyridoxal 5'-phosphate or PLP is a cofactor derived from B6 vitamers and essential for
growth in all known organisms. PLP synthesis and salvage pathways are well characterized …

Many biological functions played by current proteins were not created by evolution from
scratch, rather they were obtained combining already available protein scaffolds. This is the …

Clostridioides difficile is responsible for various intestinal symptoms from mild diarrhea to
severe pseudomembranous colitis and is the primary cause of antibiotic-associated diarrhea …

Clostridioides difficile infection (CDI) is the primary cause of health-care-associated
infectious diarrhea. Treatment requires mostly specific antibiotics such as metronidazole …

The MocR-subfamily transcription factors (MocR-TFs) characterized by the GntR-family DNA-
binding domain and aminotransferase-like sensory domain are broadly distributed among …

Cryptococcal meningitis caused by Cryptococcus neoformans, is a common opportunistic
neural infection in immunocompromised individuals. Cryptococcus meningitis is associated …

Biofilms are special microbial communities produced by many microorganisms, such as
bacteria, viruses, and fungi. Biofilms enable the microorganisms to possess the capacity …