Microorganisms produce a wealth of structurally diverse specialized metabolites with a
remarkable range of biological activities and a wide variety of applications in medicine and …

Covering: 2013 to June 2018 Heterologous expression of natural product biosynthetic
pathways is of increasing interest in microbial biotechnology, drug discovery and …

The amino acid sequence of a protein affects both its structure and its function. Thus, the
ability to modify the sequence, and hence the structure and activity, of individual proteins in …

Competitive sustainable production in industry demands new and better biocatalysts,
optimized bioprocesses and cost-effective product recovery. Our review sheds light on the …

Recent advances in Synthetic Biology have yielded standardized and automatable DNA
assembly protocols that enable a broad range of biotechnological research and …

Natural products continue to play a pivotal role in drug-discovery efforts and in the
understanding of human health. The ability to extend nature's chemistry through …

Covering: 2005 up to 2019 Natural products are of paramount importance in human
medicine. Not only are most antibacterial and anticancer drugs derived directly from or …

Natural products produced by microorganisms and plants are a major resource of
antibacterial and anticancer drugs as well as industrially useful compounds. However, the …

Polycyclic tetramate macrolactams (PTMs) are a widely distributed class of natural products
with important biological activities. However, many of these PTMs have not been …

Harnessing cell factories for producing biofuel and pharmaceutical molecules has
stimulated efforts to develop novel synthetic biology tools customized for modular pathway …