Regulation of B-cell receptor signaling and its therapeutic relevance in aggressive B-cell lymphomas
Simple Summary Dysregulated B-cell receptor (BCR) signaling is considered a potent
contributor to tumor survival in different subtypes of B-cell non-Hodgkin lymphomas (B …
contributor to tumor survival in different subtypes of B-cell non-Hodgkin lymphomas (B …
Bruton tyrosine kinase inhibitors in B-cell lymphoma: beyond the antitumour effect
H Wang, H Guo, J Yang, Y Liu, X Liu, Q Zhang… - … Hematology & Oncology, 2022 - Springer
Targeting B-cell receptor signalling using Bruton tyrosine kinase (BTK) inhibitors (BTKis) has
become a highly successful treatment modality for B-cell malignancies, especially for …
become a highly successful treatment modality for B-cell malignancies, especially for …
Correlation of Professional Antigen‐Presenting Tbet+CD11c+ B Cells With Bone Destruction in Untreated Rheumatoid Arthritis
Objective Subsets of CD21−/low memory B cells (MBCs), including double‐negative (DN,
CD27− IgD−) and Tbet+ CD11c+ cells, are expanded in chronic inflammatory diseases. In …
CD27− IgD−) and Tbet+ CD11c+ cells, are expanded in chronic inflammatory diseases. In …
Mechanical regulation of lymphocyte activation and function
Mechanosensing, or how cells sense and respond to the physical environment, is crucial for
many aspects of biological function, ranging from cell movement during development to …
many aspects of biological function, ranging from cell movement during development to …
WAVE2 Regulates Actin-Dependent Processes Induced by the B Cell Antigen Receptor and Integrins
A Bedi, K Choi, C Keane, M Bolger-Munro… - Cells, 2023 - mdpi.com
B cell antigen receptor (BCR) signaling induces actin cytoskeleton remodeling by
stimulating actin severing, actin polymerization, and the nucleation of branched actin …
stimulating actin severing, actin polymerization, and the nucleation of branched actin …
Correlation of Professional Antigen-Presenting Tbet+ CD11c+ B Cells With Bone Destruction in Untreated Rheumatoid Arthritis
Objective: Subsets of CD21−/low memory B cells (MBCs), including double-negative (DN,
CD27− IgD−) and Tbet+ CD11c+ cells, are expanded in chronic inflammatory diseases. In …
CD27− IgD−) and Tbet+ CD11c+ cells, are expanded in chronic inflammatory diseases. In …
Spatial Stochastic Model of the Pre-B Cell Receptor
R Kerketta, MF Erasmus, BS Wilson… - … ACM transactions on …, 2022 - ieeexplore.ieee.org
Survival and proliferation of immature B lymphocytes requires expression and tonic
signaling of the pre-B cell receptor (pre-BCR). This low level, ligand-independent signaling …
signaling of the pre-B cell receptor (pre-BCR). This low level, ligand-independent signaling …
Mechanical control of antigen detection and discrimination by T and B cell receptors
The adaptive immune response is orchestrated by just two cell types: T cells and B cells.
Both cells possess the remarkable ability to recognise virtually any antigen through their …
Both cells possess the remarkable ability to recognise virtually any antigen through their …
Multiscale imaging and quantitative analysis of plasma membrane protein-cortical actin interplay
A Dasgupta, HT Ngo, D Tschoerner, N Touret… - Biophysical journal, 2023 - cell.com
The spatiotemporal organization of cell surface receptors is important for cell signaling.
Cortical actin (CA), the subset of the actin cytoskeleton subjacent to the plasma membrane …
Cortical actin (CA), the subset of the actin cytoskeleton subjacent to the plasma membrane …
Antigen mobility regulates the dynamics and precision of antigen capture in the B cell immune synapse
B cells discriminate antigens in immune synapses by capturing them from antigen-
presenting cells. This discrimination relies on the application of mechanical force to B cell …
presenting cells. This discrimination relies on the application of mechanical force to B cell …