Cancer has been a leading cause of death for decades. This dismal statistic has increased
efforts to prevent the disease or to detect it early, when treatment is less invasive, relatively …

The natural history of cancers can be understood through the lens of evolution given that the
driving forces of cancer development are mutation and selection of fitter clones. Cancer …

Organ development and homeostasis involve dynamic interactions between individual cells
that collectively regulate tissue architecture and function. To ensure the highest tissue …

The translational challenges in the field of precision oncology are in part related to the
biological complexity and diversity of this disease. Technological advances in genomics …

Existing organoid models fall short of fully capturing the complexity of cancer because they
lack sufficient multicellular diversity, tissue-level organization, biological durability and …

Competition among adult brain cells has not been extensively researched. To investigate
whether healthy glia can outcompete diseased human glia in the adult forebrain, we …

Somatic mosaicism, the occurrence of multiple genetically distinct cell clones within the
same tissue, is an evitable consequence of human aging. The hematopoietic system is no …

The tumour evolution model posits that malignant transformation is preceded by randomly
distributed driver mutations in cancer genes, which cause clonal expansions in …

Missense driver mutations in cancer are concentrated in a few hotspots. Various
mechanisms have been proposed to explain this skew, including biased mutational …

Esophageal squamous cell carcinoma (ESCC) develops through a series of increasingly
abnormal precancerous lesions. Previous studies have revealed the striking differences …