Red Light-Mediated Photoredox Catalysis Triggers Nitric Oxide Release for Treatment of Cutibacterium Acne Induced Intervertebral Disc Degeneration

S Tao, Z Shen, J Chen, Z Shan, B Huang, X Zhang… - ACS …, 2022 - ACS Publications
Intervertebral disc degeneration (IVDD) has been known as a highly prevalent and disabling
disease, which is one of the main causes of low back pain and disability. Unfortunately …

Cutibacterium acnes in spine pathology: pathophysiology, diagnosis, and management

JG Khalil, SD Gandhi, DK Park… - JAAOS-Journal of the …, 2019 - journals.lww.com
Cutibacterium acnes, long thought to be skin flora of pathological insignificance, has seen a
surge in interest for its role in spine pathology. C acnes has been identified as a pathogen in …

The bacteria-positive proportion in the disc tissue samples from surgery: a systematic review and meta-analysis

Y Jiao, Y Lin, Y Zheng, Y Yuan, Z Chen, P Cao - European Spine Journal, 2019 - Springer
Purpose The role of bacteria, especially Propionibacterium acnes (P. acnes), in human
intervertebral disc diseases has raised attention in recent years. However, limited sample …

Cutibacterium acnes is an intracellular and intra-articular commensal of the human shoulder joint

R Hudek, A Brobeil, H Brüggemann, F Sommer… - Journal of shoulder and …, 2021 - Elsevier
Background Cutibacterium acnes (C acnes) is a mysterious member of the shoulder
microbiome and is associated with chronic postoperative complications and low-grade …

Damage to the human lumbar cartilage endplate and its clinical implications

B Huang, J Liu, X Wei, S Li, Y Xiang, H Wu… - Journal of …, 2021 - Wiley Online Library
The cartilaginous endplate (CEP) is a thin layer of hyaline cartilage, and plays an important
role in the diffusion of nutrients into the intervertebral discs. Its damage may seriously affect …

[HTML][HTML] Activation of Nrf2 signaling by 4-octyl itaconate attenuates the cartilaginous endplate degeneration by inhibiting E3 ubiquitin ligase ZNF598

B Huang, H Wu, L Zheng, X Wei, Z Zheng… - Osteoarthritis and …, 2023 - Elsevier
Objective Cartilaginous endplate (CEP) degeneration is the main early manifestations of
intervertebral disc degeneration (IVDD), and is closely related to the oxidative stress. Nrf2 …

Osteal tissue macrophages are involved in endplate osteosclerosis through the OSM-STAT3/YAP1 signaling axis in modic changes

J Wang, Z Zheng, B Huang, H Wu, X Zhang… - The Journal of …, 2020 - journals.aai.org
Modic changes (MCs) are radiographic manifestations of lumbar degenerative diseases.
Various types of MCs are often associated with endplate osteosclerosis. Osteal tissue …

Low virulence bacterial infections in cervical intervertebral discs: a prospective case series

Y Chen, X Wang, X Zhang, H Ren, B Huang… - European Spine …, 2018 - Springer
Study design A prospective cross-sectional case series study. Objective To investigate the
prevalence of low virulence disc infection and its associations with characteristics of patients …

Different phylotypes of Cutibacterium acnes cause different modic changes in intervertebral disc degeneration

W Lan, X Wang, X Tu, X Hu, H Lu - PloS one, 2022 - journals.plos.org
Background The contribution of Cutibacterium acnes (C. acnes) infection to intervertebral
disc degeneration (IDD) and the antibiotic therapy has evoked several controversies in …

Propionibacterium acnes incubation in the discs can result in time-dependent modic changes: A long-term rabbit model

Z Shan, X Zhang, S Li, T Yu, J Liu, F Zhao - Spine, 2017 - journals.lww.com
Study Design. A case-control study of animal model of Modic changes (MCs) on rabbits.
Objective. To evaluate the feasibility of inducing of MCs by injection of Propionibacterium …