Lipid nanoparticles for drug delivery

L Xu, X Wang, Y Liu, G Yang… - Advanced …, 2022 - Wiley Online Library
Lipid nanoparticles have attracted significant interests in the last two decades, and have
achieved tremendous clinical success since the first clinical approval of Doxil in 1995. At the …

Microfluidic technologies and devices for lipid nanoparticle-based RNA delivery

M Maeki, S Uno, A Niwa, Y Okada, M Tokeshi - Journal of Controlled …, 2022 - Elsevier
In 2021, mRNA vaccines against COVID-19 were approved by the Food and Drug
Administration. mRNA vaccines are important for preventing severe COVID-19 and returning …

Liposomes for tumor targeted therapy: a review

S Wang, Y Chen, J Guo, Q Huang - International journal of molecular …, 2023 - mdpi.com
Liposomes, the most widely studied nano-drug carriers in drug delivery, are sphere-shaped
vesicles consisting of one or more phospholipid bilayers. Compared with traditional drug …

Microfluidic nanoparticles for drug delivery

Y Liu, G Yang, Y Hui, S Ranaweera, CX Zhao - Small, 2022 - Wiley Online Library
Nanoparticles (NPs) have attracted tremendous interest in drug delivery in the past decades.
Microfluidics offers a promising strategy for making NPs for drug delivery due to its capability …

[HTML][HTML] Impact of lipid nanoparticle size on mRNA vaccine immunogenicity

KJ Hassett, J Higgins, A Woods, B Levy, Y Xia… - Journal of Controlled …, 2021 - Elsevier
Lipid nanoparticles (LNP) are effective delivery vehicles for messenger RNA (mRNA) and
have shown promise for vaccine applications. Yet there are no published reports detailing …

[HTML][HTML] Manufacturing considerations for the development of lipid nanoparticles using microfluidics

CB Roces, G Lou, N Jain, S Abraham, A Thomas… - Pharmaceutics, 2020 - mdpi.com
In the recent of years, the use of lipid nanoparticles (LNPs) for RNA delivery has gained
considerable attention, with a large number in the clinical pipeline as vaccine candidates or …

Lipid nanoparticles as delivery systems for RNA-based vaccines

BN Aldosari, IM Alfagih, AS Almurshedi - Pharmaceutics, 2021 - mdpi.com
There has been increased interest in the development of RNA-based vaccines for protection
against various infectious diseases and also for cancer immunotherapies. Rapid and cost …

Advances in microfluidics for lipid nanoparticles and extracellular vesicles and applications in drug delivery systems

M Maeki, N Kimura, Y Sato, H Harashima… - Advanced drug delivery …, 2018 - Elsevier
Lipid-based nanobiomaterials as liposomes and lipid nanoparticles (LNPs) are the most
widely used nanocarriers for drug delivery systems (DDSs). Extracellular vesicles (EVs) and …

Recent advances and applications of micromixers

CY Lee, LM Fu - Sensors and Actuators B: Chemical, 2018 - Elsevier
Micromixers are crucial components within micro biomedical systems. This article presents a
comprehensive review of the main state-of-the art applications of micromixers in biomedical …

Controllable synthesis of functional nanoparticles by microfluidic platforms for biomedical applications–a review

J Ma, SMY Lee, C Yi, CW Li - Lab on a Chip, 2017 - pubs.rsc.org
Nanoparticles have drawn significant attention in biomedicine due to their unique optical,
thermal, magnetic and electrical properties which are highly related to their size and …