Extensive effort has been devoted to the discovery, development, and validation of
biomarkers for early disease diagnosis and prognosis as well as rapid evaluation of the …

Thousands of naturally occurring peptides differing in their origin, abundance and possible
functions have been identified in the tissue and biological fluids of vertebrates, insects, fungi …

Introduction: Currently, the diagnosis of psychiatric illnesses is based upon DSM-5 criteria.
Although endophenotype-specificity for a particular disorder is discussed, the identification …

Intracellular peptides are produced by proteasomes following degradation of nuclear,
cytosolic, and mitochondrial proteins, and can be further processed by additional peptidases …

Sea anemones are sessile invertebrates of the phylum Cnidaria and their survival and
evolutive success are highly related to the ability to produce and quickly inoculate venom …

The cannabinoid system has the ability to modulate cellular and molecular mechanisms,
including excitotoxicity, oxidative stress, apoptosis, and inflammation, acting as a …

Peptidomics is the comprehensive characterization of peptides from biological sources
instead of heading for a few single peptides in former peptide research. Mass spectrometry …

Thimet oligopeptidase (EC 3.4. 24.15; EP24. 15, THOP1) is a metallopeptidase ubiquitously
distributed in mammalian tissues. Beyond its previously well characterized role in major …

Neurodegeneration is the result of progressive destruction of neurons in the central nervous
system, with unknown causes and pathological mechanisms not yet fully elucidated. Several …

Intracellular peptides (InPeps) generated by proteasomes were previously suggested as
putative natural regulators of protein–protein interactions (PPI). Here, the main aim was to …