Inflammation is an evolutionary process that allows survival against acute infection or injury.
Inflammation is also a pathophysiological condition shared by numerous chronic diseases …

The gastrointestinal tract (GIT), in particular, the small intestine, plays a significant role in
food digestion, fluid and electrolyte transport, drug absorption and metabolism, and nutrient …

Inflammatory bowel disease causes a major burden to patients and healthcare systems,
raising the need to develop effective therapies. Technological advances in cell culture, allied …

The ATP-binding cassette (ABC) transporters play a key role in drug pharmacokinetics.
These membrane transporters expressed within physiological barriers can be a source of …

Mosunetuzumab is a CD3/CD20 bispecific antibody. As an on‐target effect, transient
elevation of interleukin‐6 (IL‐6) occurs in early treatment cycles. A physiologically‐based …

Purpose For decades, inflammation has been considered a cause of pharmacokinetic
variability, mainly in relation to the inhibitory effect of pro-inflammatory cytokines on the …

Poly (2-isopropenyl-2-oxazoline)(PIPOx) represents a universal polymer platform with
pendant 2-oxazoline groups, allowing the preparation of biomaterials for various biomedical …

Background: The special environment of high-altitude hypoxia not only changes the
physiological state of the body but also affects the metabolic process of many drugs, which …

High inter-individual variability in tacrolimus clearance is attributed to genetic
polymorphisms of CYP3A enzymes. However, due to CYP3A phenoconversion induced by …

Calcineurin inhibitors (CNIs) are narrow therapeutic index medications, with drug
concentrations altered by factors such as drug-drug interactions, clinical symptoms including …